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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase Mer | ||
| Ligand | BDBM50384592 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_820659 (CHEMBL2037930) | ||
| IC50 | 56±n/a nM | ||
| Citation |  Liu, J; Yang, C; Simpson, C; Deryckere, D; Van Deusen, A; Miley, MJ; Kireev, D; Norris-Drouin, J; Sather, S; Hunter, D; Korboukh, VK; Patel, HS; Janzen, WP; Machius, M; Johnson, GL; Earp, HS; Graham, DK; Frye, SV; Wang, X Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia. ACS Med Chem Lett3:129-134 (2012) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase Mer | |||
| Name: | Tyrosine-protein kinase Mer | ||
| Synonyms: | MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 110234.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1498723 | ||
| Residue: | 999 | ||
| Sequence: |
| ||
| BDBM50384592 | |||
| n/a | |||
| Name | BDBM50384592 | ||
| Synonyms: | CHEMBL2036628 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H24N6 | ||
| Mol. Mass. | 336.4341 | ||
| SMILES | CNc1ncc2c(nn(C[C@H]3CC[C@H](N)CC3)c2n1)-c1ccccc1 |r,wU:10.9,wD:13.13,(2.58,-11.99,;3.91,-12.76,;5.24,-11.99,;5.25,-10.45,;6.57,-9.68,;7.91,-10.44,;9.38,-9.96,;10.3,-11.22,;9.38,-12.47,;9.86,-13.94,;8.83,-15.08,;9.31,-16.53,;8.27,-17.68,;6.76,-17.35,;5.73,-18.49,;6.29,-15.89,;7.32,-14.75,;7.91,-11.99,;6.58,-12.76,;9.86,-8.5,;11.37,-8.18,;11.84,-6.72,;10.81,-5.57,;9.3,-5.9,;8.83,-7.36,)| | ||
| Structure | 
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