Reaction Details |
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Target | RAC-alpha serine/threonine-protein kinase |
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Ligand | BDBM50384846 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_821275 (CHEMBL2039955) |
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IC50 | 2668±n/a nM |
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Citation | Kettle, JG; Brown, S; Crafter, C; Davies, BR; Dudley, P; Fairley, G; Faulder, P; Fillery, S; Greenwood, H; Hawkins, J; James, M; Johnson, K; Lane, CD; Pass, M; Pink, JH; Plant, H; Cosulich, SC Diverse heterocyclic scaffolds as allosteric inhibitors of AKT. J Med Chem55:1261-73 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAC-alpha serine/threonine-protein kinase |
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Name: | RAC-alpha serine/threonine-protein kinase |
Synonyms: | AKT phosphorylation (p-AKT) | AKT1 | AKT1/PPP1CA | AKT1_HUMAN | C-AKT | PKB | PKB alpha | Protein kinase Akt-1 | Protein kinase B | Protein kinase B (AKT1) | Protein kinase B (Akt 1) | Protein kinase B (Akt) | Protein kinase B alpha | Protein kinase B alpha (AKT1) | Proto-oncogene Akt (Akt1) | Proto-oncogene c-Akt (AKT) | Proto-oncogene c-Akt (AKT1) | RAC | RAC-PK-alpha | RAC-alpha serine/threonine-protein kinase (AKT) | RAC-alpha serine/threonine-protein kinase (AKT1) | RAC-alpha serine/threonine-protein kinase (pAKT) |
Type: | Enzyme |
Mol. Mass.: | 55681.25 |
Organism: | Homo sapiens (Human) |
Description: | P31749 |
Residue: | 480 |
Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
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BDBM50384846 |
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n/a |
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Name | BDBM50384846 |
Synonyms: | CHEMBL2035035 |
Type | Small organic molecule |
Emp. Form. | C22H20N4 |
Mol. Mass. | 340.421 |
SMILES | NC1(CCC1)c1ccc(cc1)-c1c(ccn2ncnc12)-c1ccccc1 |
Structure |
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