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TargetKynurenine Aminotransferase 1/Glutamine Transaminase K
LigandBDBM50386292
Substrate/Competitorn/a
Meas. Tech.ChEMBL_826600
IC50 22000±n/a nM
Citation Dounay ABAnderson MBechle BMCampbell BMClaffey MMEvdokimov AEvrard EFonseca KRGan XGhosh SHayward MMHorner WKim JYMcAllister LAPandit JParadis VParikh VDReese MRRong SSalafia MASchuyten KStrick CATuttle JBValentine JWang HZawadzke LEVerhoest PR Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett 3:187-192 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine Aminotransferase 1/Glutamine Transaminase K
Name:Kynurenine Aminotransferase 1/Glutamine Transaminase K
Synonyms:Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | Kynurenine--oxoglutarate transaminase 1
Type:Aminotransferase; Lyase
Mol. Mass.:47874.00
Organism:Homo sapiens (Human)
Description:Recombinant hKAT-1 was expressed and purified from Sf9 insect cells.
Residue:422
Sequence:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
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  Blast E-value cutoff:
BDBM50386292
n/a
NameBDBM50386292
Synonyms:CHEMBL2047851
TypeSmall organic molecule
Emp. Form.C9H10N2O2
Mol. Mass.178.1879
SMILESN[C@H]1Cc2ccccc2N(O)C1=O |r|
Structure
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