| Reaction Details |
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 | Report a problem with these data |
| Target | Kynurenine--oxoglutarate transaminase 1 |
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| Ligand | BDBM50386292 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_826600 (CHEMBL2050768) |
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| IC50 | 22000±n/a nM |
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| Citation |  Dounay, AB; Anderson, M; Bechle, BM; Campbell, BM; Claffey, MM; Evdokimov, A; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Hayward, MM; Horner, W; Kim, JY; McAllister, LA; Pandit, J; Paradis, V; Parikh, VD; Reese, MR; Rong, S; Salafia, MA; Schuyten, K; Strick, CA; Tuttle, JB; Valentine, J; Wang, H; Zawadzke, LE; Verhoest, PR Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. ACS Med Chem Lett3:187-192 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kynurenine--oxoglutarate transaminase 1 |
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| Name: | Kynurenine--oxoglutarate transaminase 1 |
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| Synonyms: | CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1 |
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| Type: | Aminotransferase; Lyase |
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| Mol. Mass.: | 47874.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant hKAT-1 was expressed and purified from Sf9 insect cells. |
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| Residue: | 422 |
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| Sequence: | MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
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| BDBM50386292 |
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| n/a |
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| Name | BDBM50386292 |
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| Synonyms: | CHEMBL2047851 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H10N2O2 |
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| Mol. Mass. | 178.1879 |
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| SMILES | N[C@H]1Cc2ccccc2N(O)C1=O |r| |
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| Structure | 
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