Reaction Details |
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Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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Ligand | BDBM50388166 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_828843 (CHEMBL2060493) |
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IC50 | 2500±n/a nM |
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Citation | Miyahara, S; Miyakoshi, H; Yokogawa, T; Chong, KT; Taguchi, J; Muto, T; Endoh, K; Yano, W; Wakasa, T; Ueno, H; Takao, Y; Fujioka, A; Hashimoto, A; Itou, K; Yamamura, K; Nomura, M; Nagasawa, H; Shuto, S; Fukuoka, M Discovery of a novel class of potent human deoxyuridine triphosphatase inhibitors remarkably enhancing the antitumor activity of thymidylate synthase inhibitors. J Med Chem55:2970-80 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
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Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
Synonyms: | DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase |
Type: | Enzyme |
Mol. Mass.: | 26574.03 |
Organism: | Homo sapiens (Human) |
Description: | P33316 |
Residue: | 252 |
Sequence: | MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA
GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS
EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH
FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE
RGSGGFGSTGKN
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BDBM50388166 |
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n/a |
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Name | BDBM50388166 |
Synonyms: | CHEMBL2057910 |
Type | Small organic molecule |
Emp. Form. | C20H27N3O6S |
Mol. Mass. | 437.51 |
SMILES | C[C@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OCC2CC2)c1 |r| |
Structure |
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