Reaction Details |
| Report a problem with these data |
Target | Procathepsin L |
---|
Ligand | BDBM50388856 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_831047 (CHEMBL2065748) |
---|
IC50 | 3650±n/a nM |
---|
Citation | Song, J; Jones, LM; Kumar, GD; Conner, ES; Bayeh, L; Chavarria, GE; Charlton-Sevcik, AK; Chen, SE; Chaplin, DJ; Trawick, ML; Pinney, KG Synthesis and biochemical evaluation of thiochromanone thiosemicarbazone analogues as inhibitors of cathepsin L. ACS Med Chem Lett3:450-453 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Procathepsin L |
---|
Name: | Procathepsin L |
Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
Type: | Enzyme |
Mol. Mass.: | 37557.19 |
Organism: | Homo sapiens (Human) |
Description: | Purchased from Calbiochem (San Diego, CA). |
Residue: | 333 |
Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
|
|
|
BDBM50388856 |
---|
n/a |
---|
Name | BDBM50388856 |
Synonyms: | CHEMBL2062915 |
Type | Small organic molecule |
Emp. Form. | C10H9F2N3O2S2 |
Mol. Mass. | 305.324 |
SMILES | NC(=S)NN=C1CCS(=O)(=O)c2cc(F)c(F)cc12 |w:4.3| |
Structure |
|