Reaction Details |
| Report a problem with these data |
Target | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
---|
Ligand | BDBM101906 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_847916 (CHEMBL2150115) |
---|
EC50 | 140±n/a nM |
---|
Citation | Miyahara, S; Miyakoshi, H; Yokogawa, T; Chong, KT; Taguchi, J; Muto, T; Endoh, K; Yano, W; Wakasa, T; Ueno, H; Takao, Y; Fujioka, A; Hashimoto, A; Itou, K; Yamamura, K; Nomura, M; Nagasawa, H; Shuto, S; Fukuoka, M Discovery of highly potent human deoxyuridine triphosphatase inhibitors based on the conformation restriction strategy. J Med Chem55:5483-96 (2012) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
---|
Name: | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial |
Synonyms: | DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase |
Type: | Enzyme |
Mol. Mass.: | 26574.03 |
Organism: | Homo sapiens (Human) |
Description: | P33316 |
Residue: | 252 |
Sequence: | MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSA
GRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLS
EHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKH
FIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTE
RGSGGFGSTGKN
|
|
|
BDBM101906 |
---|
n/a |
---|
Name | BDBM101906 |
Synonyms: | CHEMBL2147975 | US8530490, 178 |
Type | Small organic molecule |
Emp. Form. | C24H27N3O5S |
Mol. Mass. | 469.553 |
SMILES | CC(C)(NS(=O)(=O)c1cccc(OCC2CC2)c1)c1ccc(Cn2ccc(=O)[nH]c2=O)cc1 |
Structure |
|