| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate carboxypeptidase 2 |
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| Ligand | BDBM50392045 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_851405 (CHEMBL2156338) |
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| IC50 | 2±n/a nM |
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| Citation |  Stoermer, D; Vitharana, D; Hin, N; Delahanty, G; Duvall, B; Ferraris, DV; Grella, BS; Hoover, R; Rojas, C; Shanholtz, MK; Smith, KP; Stathis, M; Wu, Y; Wozniak, KM; Slusher, BS; Tsukamoto, T Design, synthesis, and pharmacological evaluation of glutamate carboxypeptidase II (GCPII) inhibitors based on thioalkylbenzoic acid scaffolds. J Med Chem55:5922-32 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate carboxypeptidase 2 |
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| Name: | Glutamate carboxypeptidase 2 |
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| Synonyms: | FGCP | FOLH | FOLH1 | FOLH1_HUMAN | Folate hydrolase 1 | Folylpoly-gamma-glutamate carboxypeptidase | Glutamate carboxypeptidase 2 | Glutamate carboxypeptidase II | Membrane glutamate carboxypeptidase | N-acetylated-alpha-linked acidic dipeptidase I | NAALAD1 | NAALADase I | PSM | PSMA | Prostate-specific membrane antigen | Pteroylpoly-gamma-glutamate carboxypeptidase | mGCP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84333.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1497035 |
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| Residue: | 750 |
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| Sequence: | MWNLLHETDSAVATARRPRWLCAGALVLAGGFFLLGFLFGWFIKSSNEATNITPKHNMKA
FLDELKAENIKKFLYNFTQIPHLAGTEQNFQLAKQIQSQWKEFGLDSVELAHYDVLLSYP
NKTHPNYISIINEDGNEIFNTSLFEPPPPGYENVSDIVPPFSAFSPQGMPEGDLVYVNYA
RTEDFFKLERDMKINCSGKIVIARYGKVFRGNKVKNAQLAGAKGVILYSDPADYFAPGVK
SYPDGWNLPGGGVQRGNILNLNGAGDPLTPGYPANEYAYRRGIAEAVGLPSIPVHPIGYY
DAQKLLEKMGGSAPPDSSWRGSLKVPYNVGPGFTGNFSTQKVKMHIHSTNEVTRIYNVIG
TLRGAVEPDRYVILGGHRDSWVFGGIDPQSGAAVVHEIVRSFGTLKKEGWRPRRTILFAS
WDAEEFGLLGSTEWAEENSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVHNLTKE
LKSPDEGFEGKSLYESWTKKSPSPEFSGMPRISKLGSGNDFEVFFQRLGIASGRARYTKN
WETNKFSGYPLYHSVYETYELVEKFYDPMFKYHLTVAQVRGGMVFELANSIVLPFDCRDY
AVVLRKYADKIYSISMKHPQEMKTYSVSFDSLFSAVKNFTEIASKFSERLQDFDKSNPIV
LRMMNDQLMFLERAFIDPLGLPDRPFYRHVIYAPSSHNKYAGESFPGIYDALFDIESKVD
PSKAWGEVKRQIYVAAFTVQAAAETLSEVA
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| BDBM50392045 |
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| n/a |
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| Name | BDBM50392045 |
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| Synonyms: | CHEMBL2152561 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14O4S |
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| Mol. Mass. | 302.345 |
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| SMILES | OC(=O)c1cccc(c1)-c1cccc(CCS)c1C(O)=O |
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| Structure | 
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