| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50392530 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_852277 (CHEMBL2155543) |
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| IC50 | 170±n/a nM |
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| Citation |  Miller, MM; Liu, Y; Jiang, J; Johnson, JA; Kamau, M; Nirschl, DS; Wang, Y; Harikrishnan, L; Taylor, DS; Chen, AY; Yin, X; Seethala, R; Peterson, TL; Zvyaga, T; Zhang, J; Huang, CS; Wexler, RR; Poss, MA; Lawrence, RM; Adam, LP; Salvati, ME Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett22:6503-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50392530 |
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| n/a |
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| Name | BDBM50392530 |
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| Synonyms: | CHEMBL2152183 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H18ClF8N3O2 |
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| Mol. Mass. | 567.859 |
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| SMILES | FC(F)C(F)(F)Oc1cc(F)cc(c1)[C@](Cc1ccccc1)(NC(=O)NCC(F)(F)F)c1ccc(Cl)cn1 |r| |
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| Structure | 
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