| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bromodomain-containing protein 2 |
|---|
| Ligand | BDBM50365463 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_852810 (CHEMBL2156117) |
|---|
| IC50 | 32.5±n/a nM |
|---|
| Citation |  Chung, CW; Coste, H; White, JH; Mirguet, O; Wilde, J; Gosmini, RL; Delves, C; Magny, SM; Woodward, R; Hughes, SA; Boursier, EV; Flynn, H; Bouillot, AM; Bamborough, P; Brusq, JM; Gellibert, FJ; Jones, EJ; Riou, AM; Homes, P; Martin, SL; Uings, IJ; Toum, J; Clement, CA; Boullay, AB; Grimley, RL; Blandel, FM; Prinjha, RK; Lee, K; Kirilovsky, J; Nicodeme, E Discovery and characterization of small molecule inhibitors of the BET family bromodomains. J Med Chem54:3827-38 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bromodomain-containing protein 2 |
|---|
| Name: | Bromodomain-containing protein 2 |
|---|
| Synonyms: | BRD2 | BRD2_HUMAN | Bromodomain and extra-terminal motif (BET) | Bromodomain-containing protein 2 | Bromodomain-containing protein 2 (BRD2) | KIAA9001 | RING3 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 88085.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P25440 |
|---|
| Residue: | 801 |
|---|
| Sequence: | MLQNVTPHNKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLTPAN
PPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQP
MDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASM
PQEEQELVVTIPKNSHKKGAKLAALQGSVTSAHQVPAVSSVSHTALYTPPPEIPTTVLNI
PHPSVISSPLLKSLHSAGPPLLAVTAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPA
SPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKEL
LSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRL
MFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTAMPPGLAKSSSES
SSEESSSESSSEEEEEEDEEDEEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQG
PISKPKRKREKKEKKKKRKAEKHRGRAGADEDDKGPRAPRPPQPKKSKKASGSGGGSAAL
GPSGFGPSGGSGTKLPKKATKTAPPALPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGE
KLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIKKP
VGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKANEKTESSSAQQVAVSRLSASSSS
SDSSSSSSSSSSSDTSDSDSG
|
|
|
|---|
| BDBM50365463 |
|---|
| n/a |
|---|
| Name | BDBM50365463 |
|---|
| Synonyms: | CHEMBL1232461 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H22ClN5O2 |
|---|
| Mol. Mass. | 423.895 |
|---|
| SMILES | CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c2cc(OC)ccc2-n2c(C)nnc12 |r,t:7| |
|---|
| Structure | 
|
|---|
Search and Browse
