Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 22 |
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Ligand | BDBM54792 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_855947 (CHEMBL2161821) |
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IC50 | 5400±n/a nM |
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Citation | Stanford, SM; Krishnamurthy, D; Falk, MD; Messina, R; Debnath, B; Li, S; Liu, T; Kazemi, R; Dahl, R; He, Y; Yu, X; Chan, AC; Zhang, ZY; Barrios, AM; Woods, VL; Neamati, N; Bottini, N Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem54:1640-54 (2011) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 22 |
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Name: | Tyrosine-protein phosphatase non-receptor type 22 |
Synonyms: | 3.1.3.48 | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP | LyP | Lymphoid phosphatase | Lymphoid phosphatase (Lyp) | PEP | PEST-domain phosphatase | PTN22_HUMAN | PTPN22 | PTPN8 | Tyrosine-protein phosphatase non-receptor type 22 (LYP) | tyrosine-protein phosphatase non-receptor type 22 isoform 1 |
Type: | n/a |
Mol. Mass.: | 91712.31 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y2R2 |
Residue: | 807 |
Sequence: | MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY
KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS
ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI
DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK
HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE
ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL
LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC
FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW
PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES
AVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS
EPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIET
YSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNS
SSFLNFGFANRFSKPKGPRNPPPTWNI
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BDBM54792 |
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n/a |
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Name | BDBM54792 |
Synonyms: | 2-(3-cyano-5,8-dimethyl-quinolin-2-yl)sulfanyl-N-(2-ethyl-6-methyl-phenyl)ethanamide | 2-(3-cyano-5,8-dimethylquinolin-2-yl)sulfanyl-N-(2-ethyl-6-methylphenyl)acetamide | 2-[(3-cyano-5,8-dimethyl-2-quinolinyl)thio]-N-(2-ethyl-6-methylphenyl)acetamide | 2-[(3-cyano-5,8-dimethyl-2-quinolyl)thio]-N-(2-ethyl-6-methyl-phenyl)acetamide | CHEMBL1713374 | MLS-0412203.0001 | cid_1450182 |
Type | Small organic molecule |
Emp. Form. | C23H23N3OS |
Mol. Mass. | 389.513 |
SMILES | CCc1cccc(C)c1NC(=O)CSc1nc2c(C)ccc(C)c2cc1C#N |
Structure |
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