| Reaction Details |
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 | Report a problem with these data |
| Target | Gastric inhibitory polypeptide receptor |
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| Ligand | BDBM50393774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_857258 (CHEMBL2160603) |
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| IC50 | 478±n/a nM |
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| Citation |  Xiong, Y; Guo, J; Candelore, MR; Liang, R; Miller, C; Dallas-Yang, Q; Jiang, G; McCann, PE; Qureshi, SA; Tong, X; Xu, SS; Shang, J; Vincent, SH; Tota, LM; Wright, MJ; Yang, X; Zhang, BB; Tata, JR; Parmee, ER Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes. J Med Chem55:6137-48 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastric inhibitory polypeptide receptor |
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| Name: | Gastric inhibitory polypeptide receptor |
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| Synonyms: | GIPR | GIPR_HUMAN | Gastric Inhibitory Polypeptide Receptor (GIPR) | Gastric inhibitory polypeptide receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53173.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1518286 |
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| Residue: | 466 |
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| Sequence: | MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPPSGLA
CNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQWGLWRDHTQCEN
PEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTRNYIHINLFTSF
MLRAAAILSRDRLLPRPGPYLGDQALALWNQALAACRTAQIVTQYCVGANYTWLLVEGVY
LHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQCWERNEVKAIWWIIR
TPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLTLVPLLGVHEVVFAPV
TEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRRGWHHCRLRRSLGEEQ
RQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESYC
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| BDBM50393774 |
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| n/a |
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| Name | BDBM50393774 |
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| Synonyms: | CHEMBL2159335 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H28Cl3N3O4 |
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| Mol. Mass. | 600.92 |
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| SMILES | CCCOc1ccc(cc1Cl)-c1cc(nn1C(C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 |
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| Structure | 
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