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TargetDual specificity protein phosphatase 2
LigandBDBM50360601
Substrate/Competitorn/a
Meas. Tech.ChEMBL_857252
IC50 9200±n/a nM
Citation Xiong YGuo JCandelore MRLiang RMiller CDallas-Yang QJiang GMcCann PEQureshi SATong XXu SSShang JVincent SHTota LMWright MJYang XZhang BBTata JRParmee ER Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-ß-alanine (MK-0893) for the treatment of type II diabetes. J Med Chem 55:6137-48 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual specificity protein phosphatase 2
Name:Dual specificity protein phosphatase 2
Synonyms:DUSP2 | Dual specificity protein phosphatase PAC-1 | PAC1
Type:PROTEIN
Mol. Mass.:34405.82
Organism:Homo sapiens (Human)
Description:ChEMBL_857252
Residue:314
Sequence:
MGLEAARELECAALGTLLRDPREAERTLLLDCRPFLAFCRRHVRAARPVPWNALLRRRAR
GPPAAVLACLLPDRALRTRLVRGELARAVVLDEGSASVAELRPDSPAHVLLAALLHETRA
GPTAVYFLRGGFDGFQGCCPDLCSEAPAPALPPTGDKTSRSDSRAPVYDQGGPVEILPYL
FLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISAWFQEAI
GFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVISPNFSF
MGQLLQFETQVLCH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50360601
n/a
NameBDBM50360601
Synonyms:CHEMBL1933349
TypeSmall organic molecule
Emp. Form.C32H27Cl2N3O4
Mol. Mass.588.48
SMILESCOc1ccc2cc(ccc2c1)-c1cc(nn1[C@@H](C)c1ccc(cc1)C(=O)NCCC(O)=O)-c1cc(Cl)cc(Cl)c1 |r|
Structure
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