| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B10 |
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| Ligand | BDBM50346601 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_857752 (CHEMBL2168779) |
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| IC50 | 4000±n/a nM |
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| Citation |  Takemura, M; Endo, S; Matsunaga, T; Soda, M; Zhao, HT; El-Kabbani, O; Tajima, K; Iinuma, M; Hara, A Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid. J Nat Prod74:1201-6 (2011) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B10 |
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| Name: | Aldo-keto reductase family 1 member B10 |
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| Synonyms: | AK1BA_HUMAN | AKR1B10 | AKR1B11 | ARL-1 | ARP | Aldo-keto reductase family 1 member B10 | Aldo-keto reductase family 1 member B10 (AKR1B10) | Aldo-keto reductase family member 1B10 (AKR1B10) | Aldose reductase-like | Aldose reductase-related protein | SI reductase | Small intestine reductase | hARP |
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| Type: | Protein |
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| Mol. Mass.: | 36024.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O60218. 1ZUA; 4JII; 4GQ0 |
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| Residue: | 316 |
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| Sequence: | MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQ
EKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGD
DLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKP
VTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAK
HKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACN
VLQSSHLEDYPFNAEY
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| BDBM50346601 |
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| n/a |
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| Name | BDBM50346601 |
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| Synonyms: | NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Oleanolic acid (OA)(Compound 1) | US11660306, Example Oleanolic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C30H48O3 |
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| Mol. Mass. | 456.7003 |
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| SMILES | CC1(C)CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O |r,c:10| |
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| Structure | 
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