| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Ligand | BDBM51138 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_864727 (CHEMBL2174994) |
|---|
| IC50 | 40000±n/a nM |
|---|
| Citation |  Sirivolu, VR; Vernekar, SK; Marchand, C; Naumova, A; Chergui, A; Renaud, A; Stephen, AG; Chen, F; Sham, YY; Pommier, Y; Wang, Z 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I. J Med Chem55:8671-84 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Name: | Tyrosyl-DNA phosphodiesterase 1 |
|---|
| Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68430.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NUW8 |
|---|
| Residue: | 608 |
|---|
| Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
|
|
|
|---|
| BDBM51138 |
|---|
| n/a |
|---|
| Name | BDBM51138 |
|---|
| Synonyms: | (5Z)-5-[(1-methyl-3-indolyl)methylidene]-4-sulfanylidene-2-thiazolidinone | (5Z)-5-[(1-methylindol-3-yl)methylene]-4-thioxo-thiazolidin-2-one | (5Z)-5-[(1-methylindol-3-yl)methylidene]-4-sulfanylidene-1,3-thiazolidin-2-one | 5-[(1-methyl-1H-indol-3-yl)methylene]-4-thioxo-1,3-thiazolidin-2-one | MLS000698017 | SMR000225303 | cid_1236521 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H10N2OS2 |
|---|
| Mol. Mass. | 274.361 |
|---|
| SMILES | Cn1cc(C=C2SC(O)=NC2=S)c2ccccc12 |w:4.3,c:8| |
|---|
| Structure | 
|
|---|
Search and Browse
