| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C8 |
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| Ligand | BDBM50397798 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_874592 (CHEMBL2186228) |
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| IC50 | 1000±n/a nM |
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| Citation |  Ashwell, MA; Lapierre, JM; Brassard, C; Bresciano, K; Bull, C; Cornell-Kennon, S; Eathiraj, S; France, DS; Hall, T; Hill, J; Kelleher, E; Khanapurkar, S; Kizer, D; Koerner, S; Link, J; Liu, Y; Makhija, S; Moussa, M; Namdev, N; Nguyen, K; Nicewonger, R; Palma, R; Szwaya, J; Tandon, M; Uppalapati, U; Vensel, D; Volak, LP; Volckova, E; Westlund, N; Wu, H; Yang, RY; Chan, TC Discovery and optimization of a series of 3-(3-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amines: orally bioavailable, selective, and potent ATP-independent Akt inhibitors. J Med Chem55:5291-310 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C8 |
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| Name: | Cytochrome P450 2C8 |
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| Synonyms: | CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase |
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| Type: | Protein |
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| Mol. Mass.: | 55839.23 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10632 |
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| Residue: | 490 |
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| Sequence: | MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
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| BDBM50397798 |
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| n/a |
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| Name | BDBM50397798 |
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| Synonyms: | CHEMBL2177836 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H26FN7O2 |
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| Mol. Mass. | 571.6036 |
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| SMILES | CC(=O)Nc1cccc(c1)-c1ccc2nc(-c3cccnc3N)n(-c3ccc(CNC(=O)c4cccc(F)c4)cc3)c2n1 |
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| Structure | 
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