| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase TTK |
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| Ligand | BDBM50396148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_874756 (CHEMBL2188370) |
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| Ki | 25±n/a nM |
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| Citation |  Estrada, AA; Liu, X; Baker-Glenn, C; Beresford, A; Burdick, DJ; Chambers, M; Chan, BK; Chen, H; Ding, X; DiPasquale, AG; Dominguez, SL; Dotson, J; Drummond, J; Flagella, M; Flynn, S; Fuji, R; Gill, A; Gunzner-Toste, J; Harris, SF; Heffron, TP; Kleinheinz, T; Lee, DW; Le Pichon, CE; Lyssikatos, JP; Medhurst, AD; Moffat, JG; Mukund, S; Nash, K; Scearce-Levie, K; Sheng, Z; Shore, DG; Tran, T; Trivedi, N; Wang, S; Zhang, S; Zhang, X; Zhao, G; Zhu, H; Sweeney, ZK Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem55:9416-33 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase TTK |
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| Name: | Dual specificity protein kinase TTK |
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| Synonyms: | Dual specificity protein kinase (TTK) | Dual specificity protein kinase TTK (MPS1) | MPS1 | MPS1L1 | Monopolar Spindle 1 (MPS1) | Monopolar Spindle 1 (Mps-1) | Monopolar Spindle 1 Kinase (MPS1) | Phosphotyrosine picked threonine-protein kinase (MPS1) | TTK | TTK_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 97086.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P33981 |
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| Residue: | 857 |
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| Sequence: | MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMAN
NPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELK
AIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEML
EIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARF
LYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQ
TSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKT
ESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQ
KHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQ
LSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVF
QVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYM
VMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRI
SIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGE
SHNSSSSKTFEKKRGKK
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| BDBM50396148 |
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| n/a |
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| Name | BDBM50396148 |
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| Synonyms: | CHEMBL2171745 | US8802674, 50 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20F3N5O3 |
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| Mol. Mass. | 411.3783 |
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| SMILES | CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1C(F)(F)F |
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| Structure | 
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