Reaction Details |
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Target | COUP transcription factor 1 |
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Ligand | BDBM50399676 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_876574 (CHEMBL2188531) |
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IC50 | >10000±n/a nM |
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Citation | Yang, J; Wang, LJ; Liu, JJ; Zhong, L; Zheng, RL; Xu, Y; Ji, P; Zhang, CH; Wang, WJ; Lin, XD; Li, LL; Wei, YQ; Yang, SY Structural optimization and structure-activity relationships of N2-(4-(4-Methylpiperazin-1-yl)phenyl)-N8-phenyl-9H-purine-2,8-diamine derivatives, a new class of reversible kinase inhibitors targeting both EGFR-activating and resistance mutations. J Med Chem55:10685-99 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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COUP transcription factor 1 |
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Name: | COUP transcription factor 1 |
Synonyms: | COT1_HUMAN | COUP transcription factor I | COUP-TF I | COUP-TF1 | EAR-3 | EAR3 | ERBAL3 | NR2F1 | Nuclear receptor subfamily 2 group F member 1 | TFCOUP1 | V-erbA-related protein 3 |
Type: | PROTEIN |
Mol. Mass.: | 46167.74 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_876574 |
Residue: | 423 |
Sequence: | MAMVVSSWRDPQDDVAGGNPGGPNPAAQAARGGGGGAGEQQQQAGSGAPHTPQTPGQPGA
PATPGTAGDKGQGPPGSGQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLTY
TCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNGDPLN
GHCYLSGYISLLLRAEPYPTSRYGSQCMQPNNIMGIENICELAARLLFSAVEWARNIPFF
PDLQITDQVSLLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIR
IFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQY
PNQPSRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMSI
QCS
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BDBM50399676 |
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n/a |
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Name | BDBM50399676 |
Synonyms: | CHEMBL2178352 | US9096601, 8-26 |
Type | Small organic molecule |
Emp. Form. | C27H32N8 |
Mol. Mass. | 468.5966 |
SMILES | CN1CCN(CC1)c1ccc(Nc2ncc3nc(Nc4ccccc4)n(C4CCCC4)c3n2)cc1 |
Structure |
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