| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-dependent insulinotropic receptor |
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| Ligand | BDBM50400391 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_877428 (CHEMBL2183225) |
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| EC50 | 1258.93±n/a nM |
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| Citation |  Katamreddy, SR; Carpenter, AJ; Ammala, CE; Boros, EE; Brashear, RL; Briscoe, CP; Bullard, SR; Caldwell, RD; Conlee, CR; Croom, DK; Hart, SM; Heyer, DO; Johnson, PR; Kashatus, JA; Minick, DJ; Peckham, GE; Ross, SA; Roller, SG; Samano, VA; Sauls, HR; Tadepalli, SM; Thompson, JB; Xu, Y; Way, JM Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists. J Med Chem55:10972-94 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucose-dependent insulinotropic receptor |
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| Name: | Glucose-dependent insulinotropic receptor |
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| Synonyms: | G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor |
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| Type: | Protein |
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| Mol. Mass.: | 36901.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8TDV5 |
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| Residue: | 335 |
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| Sequence: | MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISG
LLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGF
VAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLL
FVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTP
FLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKV
LTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
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| BDBM50400391 |
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| n/a |
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| Name | BDBM50400391 |
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| Synonyms: | CHEMBL2177765 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27FN4O5S2 |
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| Mol. Mass. | 498.591 |
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| SMILES | CC(C)S(=O)(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(cc1F)S(C)(=O)=O |
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| Structure | 
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