Reaction Details |
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Target | Leukotriene A-4 hydrolase |
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Ligand | BDBM50402402 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_886318 (CHEMBL2212808) |
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IC50 | 614±n/a nM |
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Citation | Tanis, VM; Bacani, GM; Blevitt, JM; Chrovian, CC; Crawford, S; De Leon, A; Fourie, AM; Gomez, L; Grice, CA; Herman, K; Kearney, AM; Landry-Bayle, AM; Lee-Dutra, A; Nelson, J; Riley, JP; Santillán, A; Wiener, JJ; Xue, X; Young, AL Azabenzthiazole inhibitors of leukotriene A4 hydrolase. Bioorg Med Chem Lett22:7504-11 (2012) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Leukotriene A-4 hydrolase |
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Name: | Leukotriene A-4 hydrolase |
Synonyms: | LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase |
Type: | Hydrolase; metalloprotease |
Mol. Mass.: | 69280.41 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant LTA4H. |
Residue: | 611 |
Sequence: | MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDL
TIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSI
TTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAK
EDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVT
AMLVGKDLKVD
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BDBM50402402 |
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n/a |
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Name | BDBM50402402 |
Synonyms: | CHEMBL2207731 |
Type | Small organic molecule |
Emp. Form. | C18H19N3OS |
Mol. Mass. | 325.428 |
SMILES | C(N1CCCCC1)c1ccc(Oc2nc3ccncc3s2)cc1 |
Structure |
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