Reaction Details |
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Target | ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial |
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Ligand | BDBM50404296 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_65922 (CHEMBL678317) |
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IC50 | 9170±n/a nM |
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Citation | Atwal, KS; Ahmad, S; Ding, CZ; Stein, PD; Lloyd, J; Hamann, LG; Green, DW; Ferrara, FN; Wang, P; Rogers, WL; Doweyko, LM; Miller, AV; Bisaha, SN; Schmidt, JB; Li, L; Yost, KJ; Lan, HJ; Madsen, CS N-[1-Aryl-2-(1-imidazolo)ethyl]-guanidine derivatives as potent inhibitors of the bovine mitochondrial F1F0 ATP hydrolase. Bioorg Med Chem Lett14:1027-30 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial |
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Name: | ATP synthase subunit beta,/delta,/epsilon,/gamma, mitochondrial |
Synonyms: | Mitochondrial complex V; ATP synthase |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 65924 |
Components: | This complex has 4 components. |
Component 1 |
Name: | ATP synthase subunit epsilon, mitochondrial |
Synonyms: | ATP5E | ATP5E_BOVIN | ATP5F1E | ATPase subunit epsilon |
Type: | PROTEIN |
Mol. Mass.: | 5790.87 |
Organism: | Bos taurus |
Description: | EBI_100264 |
Residue: | 51 |
Sequence: | MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAMKTSGSTIKIVKVKKE
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Component 2 |
Name: | ATP synthase subunit beta, mitochondrial |
Synonyms: | ATP5B | ATP5F1B | ATPB_BOVIN |
Type: | PROTEIN |
Mol. Mass.: | 56271.25 |
Organism: | Bos taurus |
Description: | EBI_100264 |
Residue: | 528 |
Sequence: | MLGLVGRVVAASASGALRGLSPSAPLPQAQLLLRAAPAALQPARDYAAQASPSPKAGATT
GRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLV
RGQKVLDSGAPIRIPVGPETLGRIMNVIGEPIDERGPIKTKQFAAIHAEAPEFVEMSVEQ
EILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERT
REGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQD
VLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAI
YVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDV
ARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHLGK
LVPLKETIKGFQQILAGEYDHLPEQAFYMVGPIEEAVAKADKLAEEHS
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Component 3 |
Name: | ATP synthase subunit gamma, mitochondrial |
Synonyms: | ATP5C | ATP5C1 | ATP5F1C | ATPG_BOVIN | F-ATPase gamma subunit |
Type: | PROTEIN |
Mol. Mass.: | 33081.70 |
Organism: | Bos taurus |
Description: | ChEMBL_65923 |
Residue: | 298 |
Sequence: | MFSRAGVAGLSAWTVQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAE
RELKPARVYGVGSLALYEKADIKTPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKSEAAN
LAAAGKEVKIIGVGDKIRSILHRTHSDQFLVTFKEVGRRPPTFGDASVIALELLNSGYEF
DEGSIIFNRFRSVISYKTEEKPIFSLDTISSAESMSIYDDIDADVLRNYQEYSLANIIYY
SLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
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Component 4 |
Name: | ATP synthase subunit delta, mitochondrial |
Synonyms: | ATP5D | ATP5F1D | ATPD_BOVIN | F-ATPase delta subunit |
Type: | PROTEIN |
Mol. Mass.: | 17608.84 |
Organism: | Bos taurus |
Description: | EBI_100264 |
Residue: | 168 |
Sequence: | MLPSALLRRPGLGRLVRQVRLYAEAAAAQAPAAGPGQMSFTFASPTQVFFNSANVRQVDV
PTQTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSKYFVSSGSVTVNADSSVQLLAEEAV
TLDMLDLGAAKANLEKAQSELLGAADEATRAEIQIRIEANEALVKALE
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BDBM50404296 |
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n/a |
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Name | BDBM50404296 |
Synonyms: | CHEMBL8029 |
Type | Small organic molecule |
Emp. Form. | C19H15Cl3N6 |
Mol. Mass. | 433.722 |
SMILES | Clc1cccc(NC(NC(Cn2ccnc2)c2ccc(Cl)cc2Cl)=NC#N)c1 |w:24.26| |
Structure |
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