| Reaction Details |
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 | Report a problem with these data |
| Target | Glucocorticoid receptor |
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| Ligand | BDBM50409115 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_144888 (CHEMBL749961) |
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| IC50 | 16±n/a nM |
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| Citation |  Fuhrmann, U; Hess-Stumpp, H; Cleve, A; Neef, G; Schwede, W; Hoffmann, J; Fritzemeier, KH; Chwalisz, K Synthesis and biological activity of a novel, highly potent progesterone receptor antagonist. J Med Chem43:5010-6 (2001) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucocorticoid receptor |
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| Name: | Glucocorticoid receptor |
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| Synonyms: | GCR_MOUSE | Glucocorticoid | Glucocorticoid receptor | Grl | Grl1 | Nr3c1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 86050.26 |
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| Organism: | MOUSE |
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| Description: | Glucocorticoid 0 MOUSE::P06537 |
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| Residue: | 783 |
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| Sequence: | MDSKESLAPPGRDEVPSSLLGRGRGSVMDLYKTLRGGATVKVSASSPSVAAASQADSKQQ
RILLDFSKGSASNAQQQQQQQQPQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLG
LSSGETDFRLLEESIANLNRSTSRPENPKSSTPAAGCATPTEKEFPQTHSDPSSEQQNRK
SQPGTNGGSVKLYTTDQSTFDILQDLEFSAGSPGKETNESPWRSDLLIDENLLSPLAGED
DPFLLEGDVNEDCKPLILPDTKPKIQDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVI
KQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFN
VIPPIPVGSENWNRCQGSGEDNLTSLGAMNFAGRSVFSNGYSSPGMRPDVSSPPSSSSTA
TGPPPKLCLVCSDEASVCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNC
PACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENANKTIVPAALPQLTPTLVS
LLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMT
LLQYSWMFLMAFALGWRSYRQASGNLLCFAPDLIINEQRMTLPCMYDQCKHMLFISTELQ
RLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQR
FYQLTKLLDSMHDVVENLLSYCFQTFLDKSMSIEFPEMLAEIITNQIPKYSNGNIKKLLF
HQK
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| BDBM50409115 |
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| n/a |
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| Name | BDBM50409115 |
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| Synonyms: | LONAPRISAN |
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| Type | Small organic molecule |
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| Emp. Form. | C28H29F5O3 |
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| Mol. Mass. | 508.5201 |
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| SMILES | CC(=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C(F)(F)C(F)(F)F)[C@@H]2CCC3=CC(=O)CCC3=C12 |t:30,37| |
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| Structure | 
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