Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50410551

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_321686 (CHEMBL872181)

IC50

40±n/a nM

Citation

Buck, IM; Black, JW; Cooke, T; Dunstone, DJ; Gaffen, JD; Griffin, EP; Harper, EA; Hull, RA; Kalindjian, SB; Lilley, EJ; Linney, ID; Low, CM; McDonald, IM; Pether, MJ; Roberts, SP; Shankley, NP; Shaxted, ME; Steel, KI; Sykes, DA; Tozer, MJ; Watt, GF; Walker, MK; Wright, L; Wright, PT Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists. J Med Chem48:6803-12 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

CCKBR | Cholecystokinin B | Cholecystokinin B receptor | GASR_CANLF | Gastrin/cholecystokinin type B receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

48544.19

Organism:

Dog

Description:

Cholecystokinin B 0 Dog::P30552

Residue:

453

Sequence:

MELLKLNRSAQGSGAGPGASLCRAGGALLNSSGAGNLSCEPPRLRGAGTRELELAIRVTL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVVCKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIIATWM
LSGLLMVPYPVYTAVQPAGGARALQCVHRWPSARVRQTWSVLLLLLLFFVPGVVMAVAYG
LISRELYLGLRFDEDSDSESRVRSQGGLRGGAGPGPAPPNGSCRPEGGLAGEDGDGCYVQ
LPRSRQTLELSALTAPTPGPGGGPRPYQAKLLAKKRVVRMLLVIVVLFFLCWLPLYSANT
WRAFDSSGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50410551

n/a

Name

BDBM50410551

Synonyms:

CHEMBL195007

Type

Small organic molecule

Emp. Form.

C33H39N3O3

Mol. Mass.

525.6811

SMILES

Cc1cc(C)c(-c2nc(CCC34CC5CC(CC(C5)C3)C4)c([nH]2)C(=O)Nc2ccc(C)c(c2)C(O)=O)c(C)c1 |TLB:14:15:19:13.12.18,18:17:20:13.12.14,18:13:20:17.19.16,THB:14:13:19:15.20.16,16:15:12:17.19.18,16:17:12:15.20.14|

Structure