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Target5-hydroxytryptamine receptor 6
LigandBDBM50416127
Substrate/Competitorn/a
Meas. Tech.ChEMBL_634948 (CHEMBL1117802)
Ki 63.1±n/a nM
Citation Reid, MCarlyle, ICaulfield, WLClarkson, TRCusick, FEpemolu, OGilfillan, RGoodwin, RJaap, DO'Donnell, ECPresland, JRankovic, ZSpinks, DSpinks, GThomson, AMThomson, FStrain, JWishart, G The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists. Bioorg Med Chem Lett20:3713-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 6
Name:5-hydroxytryptamine receptor 6
Synonyms:5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:46968.43
Organism:Homo sapiens (Human)
Description:P50406
Residue:440
Sequence:
MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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  Blast E-value cutoff:
BDBM50416127
n/a
NameBDBM50416127
Synonyms:CHEMBL1082765
TypeSmall organic molecule
Emp. Form.C25H28ClN3O3S2
Mol. Mass.518.091
SMILESCN(C1CCN(C)CC1)C(=O)C1CN(c2ccccc12)S(=O)(=O)c1sc2ccc(Cl)cc2c1C
Structure
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