Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50416136 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_634948 (CHEMBL1117802) |
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Ki | 31.62±n/a nM |
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Citation | Reid, M; Carlyle, I; Caulfield, WL; Clarkson, TR; Cusick, F; Epemolu, O; Gilfillan, R; Goodwin, R; Jaap, D; O'Donnell, EC; Presland, J; Rankovic, Z; Spinks, D; Spinks, G; Thomson, AM; Thomson, F; Strain, J; Wishart, G The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists. Bioorg Med Chem Lett20:3713-6 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50416136 |
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n/a |
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Name | BDBM50416136 |
Synonyms: | CHEMBL1084483 |
Type | Small organic molecule |
Emp. Form. | C28H31N3O3S |
Mol. Mass. | 489.629 |
SMILES | CN(C1CCN(C)CC1)C(=O)C1CN(c2ccccc12)S(=O)(=O)c1cccc(c1)-c1ccccc1 |
Structure |
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