Reaction Details |
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Target | P2X purinoceptor 7 |
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Ligand | BDBM50416383 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_651729 (CHEMBL1228419) |
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IC50 | 79.43±n/a nM |
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Citation | Abdi, MH; Beswick, PJ; Billinton, A; Chambers, LJ; Charlton, A; Collins, SD; Collis, KL; Dean, DK; Fonfria, E; Gleave, RJ; Lejeune, CL; Livermore, DG; Medhurst, SJ; Michel, AD; Moses, AP; Page, L; Patel, S; Roman, SA; Senger, S; Slingsby, B; Steadman, JG; Stevens, AJ; Walter, DS Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor. Bioorg Med Chem Lett20:5080-4 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2X purinoceptor 7 |
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Name: | P2X purinoceptor 7 |
Synonyms: | ATP receptor | P2RX7_RAT | P2X purinoceptor 7 | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2X7 rat | P2Z receptor | P2rx7 | Purinergic receptor |
Type: | Protein |
Mol. Mass.: | 68403.50 |
Organism: | Rattus norvegicus (Rat) |
Description: | Q64663 |
Residue: | 595 |
Sequence: | MPACCSWNDVFQYETNKVTRIQSVNYGTIKWILHMTVFSYVSFALMSDKLYQRKEPLISS
VHTKVKGVAEVTENVTEGGVTKLVHGIFDTADYTLPLQGNSFFVMTNYLKSEGQEQKLCP
EYPSRGKQCHSDQGCIKGWMDPQSKGIQTGRCIPYDQKRKTCEIFAWCPAEEGKEAPRPA
LLRSAENFTVLIKNNIDFPGHNYTTRNILPGMNISCTFHKTWNPQCPIFRLGDIFQEIGE
NFTEVAVQGGIMGIEIYWDCNLDSWSHRCQPKYSFRRLDDKYTNESLFPGYNFRYAKYYK
ENGMEKRTLIKAFGVRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLIINTYAS
TCCRSRVYPSCKCCEPCAVNEYYYRKKCEPIVEPKPTLKYVSFVDEPHIWMVDQQLLGKS
LQDVKGQEVPRPQTDFLELSRLSLSLHHSPPIPGQPEEMQLLQIEAVPRSRDSPDWCQCG
NCLPSQLPENRRALEELCCRRKPGQCITTSELFSKIVLSREALQLLLLYQEPLLALEGEA
INSKLRHCAYRSYATWRFVSQDMADFAILPSCCRWKIRKEFPKTQGQYSGFKYPY
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BDBM50416383 |
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n/a |
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Name | BDBM50416383 |
Synonyms: | CHEMBL1210558 |
Type | Small organic molecule |
Emp. Form. | C14H15Cl2N3O |
Mol. Mass. | 312.194 |
SMILES | Cc1n[nH]c(C)c1CC(=O)NCc1ccc(Cl)cc1Cl |
Structure |
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