Found 53 hits with Last Name = 'collis' and Initial = 'kl' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417280
(CHEMBL1271548)Show SMILES CN1C[C@H](N(C)C1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C14H15ClF3N3O2/c1-20-7-10(21(2)13(20)23)12(22)19-6-8-4-3-5-9(11(8)15)14(16,17)18/h3-5,10H,6-7H2,1-2H3,(H,19,22)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.631 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416599
(CHEMBL1222821)Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C15H16ClF3N2O2/c1-2-21-11(6-7-12(21)22)14(23)20-8-9-4-3-5-10(13(9)16)15(17,18)19/h3-5,11H,2,6-8H2,1H3,(H,20,23)/t11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.58 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417274
(CHEMBL1269248)Show SMILES CN1C[C@H](N(C)C1=O)C(=O)NCc1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C13H15Cl2N3O2/c1-17-7-11(18(2)13(17)20)12(19)16-6-8-3-4-9(14)5-10(8)15/h3-5,11H,6-7H2,1-2H3,(H,16,19)/t11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417273
(CHEMBL1271885)Show SMILES CN1[C@@H](CN(C1=O)c1cn(C)cn1)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C17H17ClF3N5O2/c1-24-8-13(23-9-24)26-7-12(25(2)16(26)28)15(27)22-6-10-4-3-5-11(14(10)18)17(19,20)21/h3-5,8-9,12H,6-7H2,1-2H3,(H,22,27)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.51 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416603
(CHEMBL1222883)Show SMILES CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416603
(CHEMBL1222883)Show SMILES CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.16 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417278
(CHEMBL1271767)Show SMILES CN1[C@@H](CC(F)(F)C1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C14H12ClF5N2O2/c1-22-9(5-13(16,17)12(22)24)11(23)21-6-7-3-2-4-8(10(7)15)14(18,19)20/h2-4,9H,5-6H2,1H3,(H,21,23)/t9-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.98 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417272
(CHEMBL1271604)Show SMILES CN1[C@@H](CNC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C13H13ClF3N3O2/c1-20-9(6-19-12(20)22)11(21)18-5-7-3-2-4-8(10(7)14)13(15,16)17/h2-4,9H,5-6H2,1H3,(H,18,21)(H,19,22)/t9-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.98 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417271
(CHEMBL1271769)Show SMILES CN1[C@@H](COCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C14H14ClF3N2O3/c1-20-10(6-23-7-11(20)21)13(22)19-5-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.98 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417279
(CHEMBL1271884)Show SMILES CN1[C@@H](CN(C1=O)c1nccn1C)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C17H17ClF3N5O2/c1-24-7-6-22-15(24)26-9-12(25(2)16(26)28)14(27)23-8-10-4-3-5-11(13(10)18)17(19,20)21/h3-7,12H,8-9H2,1-2H3,(H,23,27)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.98 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417270
(CHEMBL1271656)Show SMILES CN1[C@@H](CN(C1=O)c1cccnc1C)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C19H18ClF3N4O2/c1-11-14(7-4-8-24-11)27-10-15(26(2)18(27)29)17(28)25-9-12-5-3-6-13(16(12)20)19(21,22)23/h3-8,15H,9-10H2,1-2H3,(H,25,28)/t15-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.01 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416598
(CHEMBL1222820)Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C14H16Cl2N2O2/c1-2-18-12(5-6-13(18)19)14(20)17-8-9-3-4-10(15)7-11(9)16/h3-4,7,12H,2,5-6,8H2,1H3,(H,17,20)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.31 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416383
(CHEMBL1210558)Show InChI InChI=1S/C14H15Cl2N3O/c1-8-12(9(2)19-18-8)6-14(20)17-7-10-3-4-11(15)5-13(10)16/h3-5H,6-7H2,1-2H3,(H,17,20)(H,18,19) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416383
(CHEMBL1210558)Show InChI InChI=1S/C14H15Cl2N3O/c1-8-12(9(2)19-18-8)6-14(20)17-7-10-3-4-11(15)5-13(10)16/h3-5H,6-7H2,1-2H3,(H,17,20)(H,18,19) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.94 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417277
(CHEMBL1269249)Show InChI InChI=1S/C12H13Cl2N3O2/c1-17-10(6-16-12(17)19)11(18)15-5-7-2-3-8(13)4-9(7)14/h2-4,10H,5-6H2,1H3,(H,15,18)(H,16,19)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417275
(CHEMBL1271939)Show SMILES CN1[C@@H](CN(C1=O)c1cccnc1C)C(=O)NCc1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C18H18Cl2N4O2/c1-11-15(4-3-7-21-11)24-10-16(23(2)18(24)26)17(25)22-9-12-5-6-13(19)8-14(12)20/h3-8,16H,9-10H2,1-2H3,(H,22,25)/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417268
(CHEMBL1271826)Show SMILES CN1[C@@H](CN(C1=O)c1ccnc(C)c1)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C19H18ClF3N4O2/c1-11-8-13(6-7-24-11)27-10-15(26(2)18(27)29)17(28)25-9-12-4-3-5-14(16(12)20)19(21,22)23/h3-8,15H,9-10H2,1-2H3,(H,25,28)/t15-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417269
(CHEMBL1269250)Show SMILES CN1C[C@H](N(C)C1=O)C(=O)NCc1cccc(Cl)c1Cl |r| Show InChI InChI=1S/C13H15Cl2N3O2/c1-17-7-10(18(2)13(17)20)12(19)16-6-8-4-3-5-9(14)11(8)15/h3-5,10H,6-7H2,1-2H3,(H,16,19)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416618
(CHEMBL1222819)Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1cccc(Cl)c1Cl |r| Show InChI InChI=1S/C14H16Cl2N2O2/c1-2-18-11(6-7-12(18)19)14(20)17-8-9-4-3-5-10(15)13(9)16/h3-5,11H,2,6-8H2,1H3,(H,17,20)/t11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 12.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417267
(CHEMBL1271768)Show SMILES CN1[C@@H](COC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C13H12ClF3N2O3/c1-19-9(6-22-12(19)21)11(20)18-5-7-3-2-4-8(10(7)14)13(15,16)17/h2-4,9H,5-6H2,1H3,(H,18,20)/t9-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 15.8 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417276
(CHEMBL1269330)Show InChI InChI=1S/C12H13Cl2N3O2/c1-17-9(6-16-12(17)19)11(18)15-5-7-3-2-4-8(13)10(7)14/h2-4,9H,5-6H2,1H3,(H,15,18)(H,16,19)/t9-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416610
(CHEMBL1222673)Show SMILES Fc1ccc(CNC(=O)[C@@H]2CCC(=O)N2C2CCC2)c(Cl)c1 |r| Show InChI InChI=1S/C16H18ClFN2O2/c17-13-8-11(18)5-4-10(13)9-19-16(22)14-6-7-15(21)20(14)12-2-1-3-12/h4-5,8,12,14H,1-3,6-7,9H2,(H,19,22)/t14-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417265
(CHEMBL1271708)Show SMILES CN1[C@@H](CC(C)(C)C1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C16H18ClF3N2O2/c1-15(2)7-11(22(3)14(15)24)13(23)21-8-9-5-4-6-10(12(9)17)16(18,19)20/h4-6,11H,7-8H2,1-3H3,(H,21,23)/t11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417266
(CHEMBL1271655)Show SMILES CN1[C@@H](CN(CCN2CCOCC2)C1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C19H24ClF3N4O3/c1-25-15(12-27(18(25)29)6-5-26-7-9-30-10-8-26)17(28)24-11-13-3-2-4-14(16(13)20)19(21,22)23/h2-4,15H,5-12H2,1H3,(H,24,28)/t15-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25.1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416602
(CHEMBL1222882)Show SMILES CCN1[C@@H](CCCC1=O)C(=O)NCc1ccc(F)cc1Cl |r| Show InChI InChI=1S/C15H18ClFN2O2/c1-2-19-13(4-3-5-14(19)20)15(21)18-9-10-6-7-11(17)8-12(10)16/h6-8,13H,2-5,9H2,1H3,(H,18,21)/t13-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417264
(CHEMBL1271605)Show SMILES CN1[C@@H](CN(C2CCN(C)CC2)C1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C19H24ClF3N4O2/c1-25-8-6-13(7-9-25)27-11-15(26(2)18(27)29)17(28)24-10-12-4-3-5-14(16(12)20)19(21,22)23/h3-5,13,15H,6-11H2,1-2H3,(H,24,28)/t15-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416607
(CHEMBL1222669)Show InChI InChI=1S/C14H16ClFN2O2/c1-2-18-12(5-6-13(18)19)14(20)17-8-9-3-4-10(16)7-11(9)15/h3-4,7,12H,2,5-6,8H2,1H3,(H,17,20)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31.6 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50415883
(CHEMBL1095454)Show SMILES Cc1nn(c(C)c1CC(=O)NCc1ccc(F)cc1Cl)-c1ccccc1 Show InChI InChI=1S/C20H19ClFN3O/c1-13-18(14(2)25(24-13)17-6-4-3-5-7-17)11-20(26)23-12-15-8-9-16(22)10-19(15)21/h3-10H,11-12H2,1-2H3,(H,23,26) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39.8 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Rattus norvegicus (Rat)) | BDBM50417275
(CHEMBL1271939)Show SMILES CN1[C@@H](CN(C1=O)c1cccnc1C)C(=O)NCc1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C18H18Cl2N4O2/c1-11-15(4-3-7-21-11)24-10-16(23(2)18(24)26)17(25)22-9-12-5-6-13(19)8-14(12)20/h3-8,16H,9-10H2,1-2H3,(H,22,25)/t16-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 63.1 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at rat recombinant P2X7 receptor |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50417263
(CHEMBL1271707)Show SMILES CN1[C@@H](CN(C1=O)c1cccc(C)n1)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C19H18ClF3N4O2/c1-11-5-3-8-15(25-11)27-10-14(26(2)18(27)29)17(28)24-9-12-6-4-7-13(16(12)20)19(21,22)23/h3-8,14H,9-10H2,1-2H3,(H,24,28)/t14-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at human recombinant P2X7 receptor expressed in HEK293 cells by ethidium accumulation assay |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416613
(CHEMBL1222739)Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCC12CC3CC(CC(C3)C1)C2 |r,TLB:11:12:15:19.18.17,THB:13:14:17:21.12.20,13:12:15.14.19:17,20:12:15:19.18.17,20:18:15:21.13.12| Show InChI InChI=1S/C18H28N2O2/c1-2-20-15(3-4-16(20)21)17(22)19-11-18-8-12-5-13(9-18)7-14(6-12)10-18/h12-15H,2-11H2,1H3,(H,19,22)/t12?,13?,14?,15-,18?/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Rattus norvegicus (Rat)) | BDBM50416383
(CHEMBL1210558)Show InChI InChI=1S/C14H15Cl2N3O/c1-8-12(9(2)19-18-8)6-14(20)17-7-10-3-4-11(15)5-13(10)16/h3-5H,6-7H2,1-2H3,(H,17,20)(H,18,19) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of rat P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Rattus norvegicus (Rat)) | BDBM50416383
(CHEMBL1210558)Show InChI InChI=1S/C14H15Cl2N3O/c1-8-12(9(2)19-18-8)6-14(20)17-7-10-3-4-11(15)5-13(10)16/h3-5H,6-7H2,1-2H3,(H,17,20)(H,18,19) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 79.4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at rat recombinant P2X7 receptor |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416617
(CHEMBL1222743)Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C15H17F3N2O2/c1-2-20-12(6-7-13(20)21)14(22)19-9-10-4-3-5-11(8-10)15(16,17)18/h3-5,8,12H,2,6-7,9H2,1H3,(H,19,22)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416604
(CHEMBL1222604)Show SMILES CC(C)N1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl |r| Show InChI InChI=1S/C15H18ClFN2O2/c1-9(2)19-13(5-6-14(19)20)15(21)18-8-10-3-4-11(17)7-12(10)16/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,18,21)/t13-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416600
(CHEMBL1222823)Show InChI InChI=1S/C14H16ClFN2O2/c1-9(19)18-6-2-3-13(18)14(20)17-8-10-4-5-11(16)7-12(10)15/h4-5,7,13H,2-3,6,8H2,1H3,(H,17,20)/t13-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Rattus norvegicus (Rat)) | BDBM50415883
(CHEMBL1095454)Show SMILES Cc1nn(c(C)c1CC(=O)NCc1ccc(F)cc1Cl)-c1ccccc1 Show InChI InChI=1S/C20H19ClFN3O/c1-13-18(14(2)25(24-13)17-6-4-3-5-7-17)11-20(26)23-12-15-8-9-16(22)10-19(15)21/h3-10H,11-12H2,1-2H3,(H,23,26) | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of rat P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416606
(CHEMBL1222606)Show InChI InChI=1S/C13H14ClFN2O2/c1-17-11(4-5-12(17)18)13(19)16-7-8-2-3-9(15)6-10(8)14/h2-3,6,11H,4-5,7H2,1H3,(H,16,19)/t11-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416605
(CHEMBL1222602)Show SMILES CN(C(=O)c1cc(Cl)c(=O)n(Cc2c(Cl)cccc2Cl)c1)c1ccccc1 Show InChI InChI=1S/C20H15Cl3N2O2/c1-24(14-6-3-2-4-7-14)19(26)13-10-18(23)20(27)25(11-13)12-15-16(21)8-5-9-17(15)22/h2-11H,12H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416601
(CHEMBL1222881)Show InChI InChI=1S/C14H16ClFN2O2/c1-2-18-12(5-6-13(18)19)14(20)17-8-9-3-4-10(16)7-11(9)15/h3-4,7,12H,2,5-6,8H2,1H3,(H,17,20)/t12-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416608
(CHEMBL1222670)Show SMILES CCCN1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl |r| Show InChI InChI=1S/C15H18ClFN2O2/c1-2-7-19-13(5-6-14(19)20)15(21)18-9-10-3-4-11(17)8-12(10)16/h3-4,8,13H,2,5-7,9H2,1H3,(H,18,21)/t13-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Rattus norvegicus (Rat)) | BDBM50416603
(CHEMBL1222883)Show SMILES CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Antagonist activity at rat recombinant P2X7 receptor |
Bioorg Med Chem Lett 20: 6370-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.101 BindingDB Entry DOI: 10.7270/Q2NC62GP |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Rattus norvegicus (Rat)) | BDBM50416605
(CHEMBL1222602)Show SMILES CN(C(=O)c1cc(Cl)c(=O)n(Cc2c(Cl)cccc2Cl)c1)c1ccccc1 Show InChI InChI=1S/C20H15Cl3N2O2/c1-24(14-6-3-2-4-7-14)19(26)13-10-18(23)20(27)25(11-13)12-15-16(21)8-5-9-17(15)22/h2-11H,12H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of rat P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Rattus norvegicus (Rat)) | BDBM50416603
(CHEMBL1222883)Show SMILES CN1[C@@H](CCC1=O)C(=O)NCc1cccc(c1Cl)C(F)(F)F |r| Show InChI InChI=1S/C14H14ClF3N2O2/c1-20-10(5-6-11(20)21)13(22)19-7-8-3-2-4-9(12(8)15)14(16,17)18/h2-4,10H,5-7H2,1H3,(H,19,22)/t10-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of rat P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416604
(CHEMBL1222604)Show SMILES CC(C)N1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl |r| Show InChI InChI=1S/C15H18ClFN2O2/c1-9(2)19-13(5-6-14(19)20)15(21)18-8-10-3-4-11(17)7-12(10)16/h3-4,7,9,13H,5-6,8H2,1-2H3,(H,18,21)/t13-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416609
(CHEMBL1222671)Show SMILES CC(C)CN1[C@@H](CCC1=O)C(=O)NCc1ccc(F)cc1Cl |r| Show InChI InChI=1S/C16H20ClFN2O2/c1-10(2)9-20-14(5-6-15(20)21)16(22)19-8-11-3-4-12(18)7-13(11)17/h3-4,7,10,14H,5-6,8-9H2,1-2H3,(H,19,22)/t14-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 398 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416611
(CHEMBL1222519)Show SMILES Fc1ccc(CNC(=O)[C@@H]2CCC(=O)N2C2CCCC2)c(Cl)c1 |r| Show InChI InChI=1S/C17H20ClFN2O2/c18-14-9-12(19)6-5-11(14)10-20-17(23)15-7-8-16(22)21(15)13-3-1-2-4-13/h5-6,9,13,15H,1-4,7-8,10H2,(H,20,23)/t15-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 501 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416616
(CHEMBL1222740)Show InChI InChI=1S/C14H17ClN2O2/c1-2-17-12(7-8-13(17)18)14(19)16-9-10-5-3-4-6-11(10)15/h3-6,12H,2,7-9H2,1H3,(H,16,19)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416614
(CHEMBL1222742)Show InChI InChI=1S/C14H17ClN2O2/c1-2-17-12(7-8-13(17)18)14(19)16-9-10-3-5-11(15)6-4-10/h3-6,12H,2,7-9H2,1H3,(H,16,19)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |
P2X purinoceptor 7
(Homo sapiens (Human)) | BDBM50416615
(CHEMBL1222744)Show SMILES CCN1[C@@H](CCC1=O)C(=O)NCc1ccccc1C(F)(F)F |r| Show InChI InChI=1S/C15H17F3N2O2/c1-2-20-12(7-8-13(20)21)14(22)19-9-10-5-3-4-6-11(10)15(16,17)18/h3-6,12H,2,7-9H2,1H3,(H,19,22)/t12-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 631 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of human P2X7 receptor by ethidium bromide release assay |
Bioorg Med Chem Lett 20: 5080-4 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.033 BindingDB Entry DOI: 10.7270/Q289173T |
More data for this Ligand-Target Pair | |