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TargetPeroxisome proliferator-activated receptor gamma
LigandBDBM50002871
Substrate/Competitorn/a
Meas. Tech.ChEMBL_438960 (CHEMBL889304)
Ki 309±n/a nM
Citation Trump, RP; Cobb, JE; Shearer, BG; Lambert, MH; Nolte, RT; Willson, TM; Buckholz, RG; Zhao, SM; Leesnitzer, LM; Iannone, MA; Pearce, KH; Billin, AN; Hoekstra, WJ Co-crystal structure guided array synthesis of PPARgamma inverse agonists. Bioorg Med Chem Lett17:3916-20 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peroxisome proliferator-activated receptor gamma
Name:Peroxisome proliferator-activated receptor gamma
Synonyms:NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:Nuclear Receptor
Mol. Mass.:57613.46
Organism:Homo sapiens (Human)
Description:P37231
Residue:505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
LQVIKKTETDMSLHPLLQEIYKDLY
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  Blast E-value cutoff:
BDBM50002871
n/a
NameBDBM50002871
Synonyms:CHEMBL396987
TypeSmall organic molecule
Emp. Form.C41H43N3O5
Mol. Mass.657.7972
SMILESCc1oc(nc1CCOc1ccc(C[C@@H](CNC(=O)C2CCC(O)CC2)Nc2ccccc2C(=O)c2ccccc2)cc1)-c1ccccc1 |wU:14.27,(2.33,-4.31,;1.09,-5.24,;-.38,-4.78,;-1.27,-6.05,;-.34,-7.28,;1.12,-6.78,;2.44,-7.56,;3.79,-6.81,;5.11,-7.6,;6.45,-6.84,;7.77,-7.63,;9.12,-6.88,;9.14,-5.34,;10.48,-4.58,;11.8,-5.37,;13.15,-4.61,;14.47,-5.4,;15.81,-4.64,;15.83,-3.1,;17.14,-5.43,;17.11,-6.96,;18.43,-7.75,;19.78,-7,;21.1,-7.79,;19.8,-5.46,;18.47,-4.66,;11.79,-6.91,;13.11,-7.69,;14.45,-6.93,;15.77,-7.71,;15.76,-9.26,;14.42,-10.01,;13.09,-9.23,;11.75,-9.98,;10.42,-9.2,;11.73,-11.52,;10.39,-12.27,;10.37,-13.81,;11.69,-14.6,;13.04,-13.84,;13.05,-12.3,;7.8,-4.55,;6.47,-5.31,;-2.81,-6.07,;-3.6,-4.75,;-5.14,-4.77,;-5.89,-6.12,;-5.11,-7.44,;-3.56,-7.42,)|
Structure
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