Reaction Details |
| Report a problem with these data |
Target | Kynurenine--oxoglutarate transaminase 1 |
---|
Ligand | BDBM50386292 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_939755 (CHEMBL2329108) |
---|
IC50 | 30400±n/a nM |
---|
Citation | Tuttle, JB; Anderson, M; Bechle, BM; Campbell, BM; Chang, C; Dounay, AB; Evrard, E; Fonseca, KR; Gan, X; Ghosh, S; Horner, W; James, LC; Kim, JY; McAllister, LA; Pandit, J; Parikh, VD; Rago, BJ; Salafia, MA; Strick, CA; Zawadzke, LE; Verhoest, PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett4:37-40 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Kynurenine--oxoglutarate transaminase 1 |
---|
Name: | Kynurenine--oxoglutarate transaminase 1 |
Synonyms: | CCBL1 | Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | KAT1_HUMAN | KYAT1 | Kynurenine Aminotransferase 1/Glutamine Transaminase K | Kynurenine--oxoglutarate transaminase 1 |
Type: | Aminotransferase; Lyase |
Mol. Mass.: | 47874.00 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hKAT-1 was expressed and purified from Sf9 insect cells. |
Residue: | 422 |
Sequence: | MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
|
|
|
BDBM50386292 |
---|
n/a |
---|
Name | BDBM50386292 |
Synonyms: | CHEMBL2047851 |
Type | Small organic molecule |
Emp. Form. | C9H10N2O2 |
Mol. Mass. | 178.1879 |
SMILES | N[C@H]1Cc2ccccc2N(O)C1=O |r| |
Structure |
|