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TargetKynurenine Aminotransferase 1/Glutamine Transaminase K
LigandBDBM50386292
Substrate/Competitorn/a
Meas. Tech.ChEMBL_939755
IC50 30400±n/a nM
Citation Tuttle JBAnderson MBechle BMCampbell BMChang CDounay ABEvrard EFonseca KRGan XGhosh SHorner WJames LCKim JYMcAllister LAPandit JParikh VDRago BJSalafia MAStrick CAZawadzke LEVerhoest PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett 4:37-40 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine Aminotransferase 1/Glutamine Transaminase K
Name:Kynurenine Aminotransferase 1/Glutamine Transaminase K
Synonyms:Cysteine-S-conjugate beta-lyase | Glutamine--phenylpyruvate transaminase | Kynurenine--oxoglutarate transaminase 1
Type:Aminotransferase; Lyase
Mol. Mass.:47874.00
Organism:Homo sapiens (Human)
Description:Recombinant hKAT-1 was expressed and purified from Sf9 insect cells.
Residue:422
Sequence:
MAKQLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHAVSGDFML
NQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGALFTAFQALVDEGDEVII
IEPFFDCYEPMTMMAGGRPVFVSLKPGPIQNGELGSSSNWQLDPMELAGKFTSRTKALVL
NTPNNPLGKVFSREELELVASLCQQHDVVCITDEVYQWMVYDGHQHISIASLPGMWERTL
TIGSAGKTFSATGWKVGWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFR
QPSSYFVQFPQAMQRCRDHMIRSLQSVGLKPIIPQGSYFLITDISDFKRKMPDLPGAVDE
PYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEATLQAMDEKLRKWKV
EL
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  Blast E-value cutoff:
BDBM50386292
n/a
NameBDBM50386292
Synonyms:CHEMBL2047851
TypeSmall organic molecule
Emp. Form.C9H10N2O2
Mol. Mass.178.1879
SMILESN[C@H]1Cc2ccccc2N(O)C1=O |r|
Structure
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