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Reaction Details
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TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial
LigandBDBM50426340
Substrate/Competitorn/a
Meas. Tech.ChEMBL_939756
Ki 1.7±n/a nM
Citation Tuttle JBAnderson MBechle BMCampbell BMChang CDounay ABEvrard EFonseca KRGan XGhosh SHorner WJames LCKim JYMcAllister LAPandit JParikh VDRago BJSalafia MAStrick CAZawadzke LEVerhoest PR Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions. ACS Med Chem Lett 4:37-40 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Name:Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms:2-aminoadipate aminotransferase | 2-aminoadipate transaminase | AADAT | Alpha-aminoadipate aminotransferase | KAT/AadAT | KAT2 | Kynurenine aminotransferase II | Kynurenine aminotransferase II (KAT II) | Kynurenine--oxoglutarate aminotransferase II | Kynurenine--oxoglutarate transaminase 2 | Kynurenine--oxoglutarate transaminase II
Type:Enzyme
Mol. Mass.:47353.09
Organism:Homo sapiens (Human)
Description:Q8N5Z0
Residue:425
Sequence:
MNYARFITAASAARNPSPIRTMTDILSRGPKSMISLAGGLPNPNMFPFKTAVITVENGKT
IQFGEEMMKRALQYSPSAGIPELLSWLKQLQIKLHNPPTIHYPPSQGQMDLCVTSGSQQG
LCKVFEMIINPGDNVLLDEPAYSGTLQSLHPLGCNIINVASDESGIVPDSLRDILSRWKP
EDAKNPQKNTPKFLYTVPNGNNPTGNSLTSERKKEIYELARKYDFLIIEDDPYYFLQFNK
FRVPTFLSMDVDGRVIRADSFSKIISSGLRIGFLTGPKPLIERVILHIQVSTLHPSTFNQ
LMISQLLHEWGEEGFMAHVDRVIDFYSNQKDAILAAADKWLTGLAEWHVPAAGMFLWIKV
KGINDVKELIEEKAVKMGVLMLPGNAFYVDSSAPSPYLRASFSSASPEQMDVAFQVLAQL
IKESL
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  Blast E-value cutoff:
BDBM50426340
n/a
NameBDBM50426340
Synonyms:CHEMBL2321943
TypeSmall organic molecule
Emp. Form.C16H16N2O4
Mol. Mass.300.3092
SMILESCOc1cc2N(O)C(=O)[C@@H](N)Cc2cc1Oc1ccccc1 |r|
Structure
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