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TargetCytochrome P450 2D6 (2D6)
LigandBDBM50426351
Substrate/Competitorn/a
Meas. Tech.ChEMBL_939926
IC50 3900±n/a nM
Citation Brown DGBernstein PRWu YUrbanek RABecker CWThroner SRDembofsky BTSteelman GBLazor LAScott CWWood MWWesolowski SSNugiel DAKoch SYu JPivonka DELi SThompson CZacco AElmore CSSchroeder PLiu JHurley CAWard SHunt HJWilliams KMcLaughlin JHoesch VSydserff SMaier DAharony D Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity. ACS Med Chem Lett 4:46-51 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6 (2D6)
Name:Cytochrome P450 2D6
Synonyms:CYPIID6 | Cytochrome P450 2D6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50426351
n/a
NameBDBM50426351
Synonyms:CHEMBL2321999
TypeSmall organic molecule
Emp. Form.C12H13Cl2N
Mol. Mass.242.144
SMILESClc1ccc(cc1Cl)[C@@H]1CNCC=CC1 |r,c:13|
Structure
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