| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily B member 2 |
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| Ligand | BDBM50004798 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_938834 (CHEMBL2328103) |
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| IC50 | 100±n/a nM |
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| Citation |  Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA Ion channels as therapeutic targets: a drug discovery perspective. J Med Chem56:593-624 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily B member 2 |
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| Name: | Potassium voltage-gated channel subfamily B member 2 |
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| Synonyms: | KCNB2 | KCNB2_HUMAN | Voltage-gated potassium channel subunit Kv2.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 102555.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105708 |
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| Residue: | 911 |
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| Sequence: | MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTR
LGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFG
QELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMREREGEEFDNTCCPDKRKKLW
DLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQETDEFGQLNDNRQLAHVEAVC
IAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV
QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDE
DATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNF
SEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANTKD
SADDNHLSPSRWKWARKALSETSSNKSFENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKL
EMLYNEITKTQPHSHPNPDCQEKPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKST
SSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGTEEHQRARGPPFLTLSREKGP
AARDGTLEYAPVDITVNLDASGSQCGLHSPLQSDNATDSPKSSLKGSNPLKSRSLKVNFK
ENRGSAPQTPPSTARPLPVTTADFSLTTPQHISTILLEETPSQGDRPLLGTEVSAPCQGP
SKGLSPRFPKQKLFPFSSRERRSFTEIDTGDDEDFLELPGAREEKQVDSSPNCFADKPSD
GRDPLREEGSVGSSSPQDTGHNCRQDIYHAVSEVKKDSSQEGCKMENHLFAPEIHSNPGD
TGYCPTRETSM
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| BDBM50004798 |
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| n/a |
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| Name | BDBM50004798 |
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| Synonyms: | CHEMBL2324356 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N3O2 |
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| Mol. Mass. | 353.458 |
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| SMILES | CC(C)C(=O)Nc1ccc(N(C)C)c(c1)C(=O)N[C@@H](C)c1ccccc1 |r| |
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| Structure | 
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