| Reaction Details |
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 | Report a problem with these data |
| Target | Acid-sensing ion channel 3 |
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| Ligand | BDBM50157090 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_938637 (CHEMBL2327257) |
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| IC50 | 9500±n/a nM |
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| Citation |  Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA Ion channels as therapeutic targets: a drug discovery perspective. J Med Chem56:593-624 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acid-sensing ion channel 3 |
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| Name: | Acid-sensing ion channel 3 |
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| Synonyms: | ASIC3_RAT | Accn3 | Amiloride-sensitive cation channel 3 | Asic3 | Drasic |
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| Type: | PROTEIN |
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| Mol. Mass.: | 59229.99 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_938637 |
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| Residue: | 533 |
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| Sequence: | MKPRSGLEEAQRRQASDIRVFASSCTMHGLGHIFGPGGLTLRRGLWATAVLLSLAAFLYQ
VAERVRYYGEFHHKTTLDERESHQLTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDP
AEHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDCRYRGQPCGPENFTVI
FTRMGQCYTFNSGAHGAELLTTPKGGAGNGLEIMLDVQQEEYLPIWKDMEETPFEVGIRV
QIHSQDEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASLDPDDFDPEPSDP
LGSPRPRPSPPYSLIGCRLACESRYVARKCGCRMMHMPGNSPVCSPQQYKDCASPALDAM
LRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLARKYNRSESYITENVLVLDIFFEAL
NYEAVEQKAAYEVSELLGDIGGQMGLFIGASLLTILEILDYLCEVFQDRVLGYFWNRRSA
QKRSGNTLLQEELNGHRTHVPHLSLGPRPPTTPCAVTKTLSASHRTCYLVTRL
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| BDBM50157090 |
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| n/a |
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| Name | BDBM50157090 |
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| Synonyms: | 6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)cyclopropyl)-2-naphthimidamide | 6-[2-(1-Isopropyl-2-methyl-1,2,3,4-tetrahydro-isoquinolin-7-yl)-cyclopropyl]-naphthalene-2-carboxamidine | CHEMBL185515 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31N3 |
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| Mol. Mass. | 397.5551 |
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| SMILES | CC(C)C1N(C)CCc2ccc(cc12)C1CC1c1ccc2cc(ccc2c1)C(N)=N |
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| Structure | 
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