| Reaction Details |
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 | Report a problem with these data |
| Target | Hypoxanthine-guanine phosphoribosyltransferase |
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| Ligand | BDBM50427808 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_940694 (CHEMBL2329985) |
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| Ki | 600±n/a nM |
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| Citation |  Keough, DT; Špacek, P; Hocková, D; Tichý, T; Vrbková, S; Slavetínská, L; Janeba, Z; Naesens, L; Edstein, MD; Chavchich, M; Wang, TH; de Jersey, J; Guddat, LW Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity. J Med Chem56:2513-26 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hypoxanthine-guanine phosphoribosyltransferase |
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| Name: | Hypoxanthine-guanine phosphoribosyltransferase |
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| Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
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| Type: | Protein |
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| Mol. Mass.: | 24579.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00492 |
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| Residue: | 218 |
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| Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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| BDBM50427808 |
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| n/a |
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| Name | BDBM50427808 |
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| Synonyms: | CHEMBL2325754 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H21N5O9P2 |
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| Mol. Mass. | 441.2708 |
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| SMILES | Nc1nc2n(CC(COCCP(O)(O)=O)OCCP(O)(O)=O)cnc2c(=O)[nH]1 |
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| Structure | 
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