| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-serine O-palmitoleoyltransferase porcupine |
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| Ligand | BDBM50428009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_941167 (CHEMBL2330993) |
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| EC50 | 0.300000±n/a nM |
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| Citation |  Wang, X; Moon, J; Dodge, ME; Pan, X; Zhang, L; Hanson, JM; Tuladhar, R; Ma, Z; Shi, H; Williams, NS; Amatruda, JF; Carroll, TJ; Lum, L; Chen, C The development of highly potent inhibitors for porcupine. J Med Chem56:2700-4 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-serine O-palmitoleoyltransferase porcupine |
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| Name: | Protein-serine O-palmitoleoyltransferase porcupine |
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| Synonyms: | PORCN_MOUSE | Porc | Porcn | Ppn | Probable protein-cysteine N-palmitoyltransferase porcupine | Protein-cysteine N-palmitoyltransferase porcupine | mPORC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52528.36 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_941167 |
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| Residue: | 461 |
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| Sequence: | MATFSRQEFFQQLLQGCLLPTVQQGLDQIWLLLTICFACRLLWRLGLPSYLKHASTVAGG
FFSLYHFFQLHMVWVVLLSLLCYLVLFLCRHSSHRGVFLSVTILIYLLMGEMHMVDTVTW
HKMRGAQMIVAMKAVSLGFDLDRGEVGAVPSPVEFMGYLYFVGTIVFGPWISFHSYLQAV
QGRPLSRRWLKKVARSLALALLCLVLSTCVGPYLFPYFIPLDGDRLLRNKKRKARGTMVR
WLRAYESAVSFHFSNYFVGFLSEATATLAGAGFTEEKDHLEWDLTVSRPLNVELPRSMVE
VVTSWNLPMSYWLNNYVFKNALRLGTFSAVLVTYAASALLHGFSFHLAAVLLSLAFITYV
EHVLRKRLAQILSACILSKRCLPDCSHRHRLGLGVRALNLLFGALAIFHLSYLGSLFDVD
VDDTTEEQGYGMAYTVHKWSELSWASHWVTFGCWIFYRLIG
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| BDBM50428009 |
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| n/a |
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| Name | BDBM50428009 |
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| Synonyms: | CHEMBL2323230 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H20N4O2S2 |
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| Mol. Mass. | 472.582 |
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| SMILES | O=C(CSc1nc2CCSc2c(=O)n1-c1ccccc1)Nc1ccc(nc1)-c1ccccc1 |
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| Structure | 
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