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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Proto-oncogene tyrosine-protein kinase Src | ||
| Ligand | BDBM50299218 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_947987 (CHEMBL2344637) | ||
| IC50 | 1.1±n/a nM | ||
| Citation |  Lafleur, K; Dong, J; Huang, D; Caflisch, A; Nevado, C Optimization of inhibitors of the tyrosine kinase EphB4. 2. Cellular potency improvement and binding mode validation by X-ray crystallography. J Med Chem56:84-96 (2013) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Proto-oncogene tyrosine-protein kinase Src | |||
| Name: | Proto-oncogene tyrosine-protein kinase Src | ||
| Synonyms: | Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src | ||
| Type: | Protein | ||
| Mol. Mass.: | 59838.60 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P12931 | ||
| Residue: | 536 | ||
| Sequence: |
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| BDBM50299218 | |||
| n/a | |||
| Name | BDBM50299218 | ||
| Synonyms: | 8-(2-Methoxyphenyl)-1-methyl-7-(2'-methyl-5'-hydroxyphenyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione | CHEMBL566515 | Cpd66 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H19N5O4 | ||
| Mol. Mass. | 417.4174 | ||
| SMILES | COc1ccccc1-n1c(cn2c1nc1n(C)c(=O)[nH]c(=O)c21)-c1cc(O)ccc1C |(16.89,-42.99,;16.89,-41.45,;18.23,-40.68,;19.55,-41.45,;20.88,-40.68,;20.88,-39.14,;19.55,-38.38,;18.23,-39.15,;16.9,-38.38,;16.91,-36.84,;15.44,-36.35,;14.53,-37.6,;15.43,-38.85,;14.53,-40.09,;13.06,-39.61,;11.74,-40.37,;11.73,-41.91,;10.41,-39.61,;9.07,-40.38,;10.41,-38.07,;11.74,-37.29,;11.74,-35.75,;13.06,-38.07,;18.24,-36.06,;19.58,-36.83,;20.9,-36.05,;22.24,-36.81,;20.9,-34.51,;19.55,-33.75,;18.23,-34.53,;16.89,-33.77,)| | ||
| Structure | 
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