| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Platelet-activating factor acetylhydrolase |
|---|
| Ligand | BDBM50429070 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_943196 (CHEMBL2346227) |
|---|
| IC50 | 27±n/a nM |
|---|
| Citation |  Hu, Y; Lin, EC; Pham, LM; Cajica, J; Amantea, CM; Okerberg, E; Brown, HE; Fraser, A; Du, L; Kohno, Y; Ishiyama, J; Kozarich, JW; Shreder, KR Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependent inhibitors of Lp-PLA2. Bioorg Med Chem Lett23:1553-6 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Platelet-activating factor acetylhydrolase |
|---|
| Name: | Platelet-activating factor acetylhydrolase |
|---|
| Synonyms: | 1-alkyl-2-acetylglycerophosphocholine esterase | 2-acetyl-1-alkylglycerophosphocholine esterase | LDL-PLA(2) | LDL-associated phospholipase A2 | PAF 2-acylhydrolase | PAF acetylhydrolase | PAFAH | PAFA_HUMAN | PLA2G7 | Platelet-activating factor acetylhydrolase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50084.41 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_156212 |
|---|
| Residue: | 441 |
|---|
| Sequence: | MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGN
GPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNI
LRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHR
DRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDID
HGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMF
PLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFA
TGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGT
NINTTNQHIMLQNSSGIEKYN
|
|
|
|---|
| BDBM50429070 |
|---|
| n/a |
|---|
| Name | BDBM50429070 |
|---|
| Synonyms: | CHEMBL2335742 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H15N3O4S |
|---|
| Mol. Mass. | 357.384 |
|---|
| SMILES | CS(=O)(=O)Nc1cccc2c(O)cc(nc12)C(=O)Nc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
