| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
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| Ligand | BDBM50430581 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_946805 (CHEMBL2345024) |
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| IC50 | 3080±n/a nM |
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| Citation |  Wang, ZG; Chen, L; Chen, J; Zheng, JF; Gao, W; Zeng, Z; Zhou, H; Zhang, XK; Huang, PQ; Su, Y Synthesis and SAR study of modulators inhibiting tRXRa-dependent AKT activation. Eur J Med Chem62:632-48 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-alpha |
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| Name: | Retinoic acid receptor RXR-alpha |
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| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50820.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456363 |
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| Residue: | 462 |
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| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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| BDBM50430581 |
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| n/a |
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| Name | BDBM50430581 |
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| Synonyms: | CHEMBL2337789 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26O3 |
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| Mol. Mass. | 362.4614 |
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| SMILES | CCOc1ccc2\C(=C/c3ccc(cc3)C(C)C)C(C)=C(CC(O)=O)c2c1 |t:20| |
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| Structure | 
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