Reaction Details |
| Report a problem with these data |
Target | Prolyl endopeptidase FAP |
---|
Ligand | BDBM50200723 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_949253 (CHEMBL2346129) |
---|
IC50 | 93±n/a nM |
---|
Citation | Poplawski, SE; Lai, JH; Li, Y; Jin, Z; Liu, Y; Wu, W; Wu, Y; Zhou, Y; Sudmeier, JL; Sanford, DG; Bachovchin, WW Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem56:3467-77 (2013) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prolyl endopeptidase FAP |
---|
Name: | Prolyl endopeptidase FAP |
Synonyms: | 170 kDa melanoma membrane-bound gelatinase | FAP | Fibroblast Activation Protein (FAP) | Fibroblast activation protein alpha | Integral membrane serine protease | SEPR_HUMAN | Seprase |
Type: | Enzyme |
Mol. Mass.: | 87712.48 |
Organism: | Homo sapiens (Human) |
Description: | Q12884 |
Residue: | 760 |
Sequence: | MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPN
WISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSK
LWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP
FQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYG
DEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVT
DERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYD
AISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPG
RRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGR
TDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQV
YGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQ
ITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVY
TERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA
QVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD
|
|
|
BDBM50200723 |
---|
n/a |
---|
Name | BDBM50200723 |
Synonyms: | (R)-1-(2-(1-oxoisoindolin-2-yl)acetyl)pyrrolidin-2-ylboronic acid | CHEMBL387050 |
Type | Small organic molecule |
Emp. Form. | C14H17BN2O4 |
Mol. Mass. | 288.107 |
SMILES | OB(O)[C@@H]1CCCN1C(=O)CN1Cc2ccccc2C1=O |
Structure |
|