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TargetHistamine H4 Receptor
LigandBDBM50433359
Substrate/Competitorn/a
Meas. Tech.ChEMBL_955840
Ki 15±n/a nM
Citation Andaloussi MLim HDvan der Meer TSijm MPoulie CBde Esch IJLeurs RSmits RA A novel series of histamine H4 receptor antagonists based on the pyrido[3,2-d]pyrimidine scaffold: comparison of hERG binding and target residence time with PF-3893787. Bioorg Med Chem Lett 23:2663-70 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 Receptor
Name:Histamine H4 Receptor
Synonyms:HH4R
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44272.75
Organism:Mus musculus (mouse)
Description:Cell pellets from SK-N-MC cells transfected with mouse H4 receptor were used in binding assay.
Residue:391
Sequence:
MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAIS
DFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAV
SYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTIT
MLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSN
PGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRG
RKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLY
PLCHRRFQKAFWKILCVTKQPALSQNQSVSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50433359
n/a
NameBDBM50433359
Synonyms:CHEMBL2376804
TypeSmall organic molecule
Emp. Form.C14H18N6
Mol. Mass.270.3329
SMILESCNC1CN(C1)c1nc(N)nc2cc(cnc12)C1CC1
Structure
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