| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen [starch] synthase, muscle |
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| Ligand | BDBM50433690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_959319 (CHEMBL2384006) |
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| EC50 | 200±n/a nM |
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| Citation |  Qian, Y; Bolin, D; Conde-Knape, K; Gillespie, P; Hayden, S; Huang, KS; Olivier, AR; Sato, T; Xiang, Q; Yun, W; Zhang, X Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators. Bioorg Med Chem Lett23:2936-40 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen [starch] synthase, muscle |
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| Name: | Glycogen [starch] synthase, muscle |
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| Synonyms: | GYS | GYS1 | GYS1_HUMAN | Glycogen [starch] synthase, muscle | Glycogen synthase (GYS1) | Muscle glycogen synthase |
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| Type: | Enzyme |
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| Mol. Mass.: | 83779.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P13807 |
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| Residue: | 737 |
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| Sequence: | MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGD
NYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVG
ASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFH
EWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYH
RYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQS
KARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQ
TVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKML
DKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPE
FLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEE
HIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKY
LGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDE
EDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLS
TPSEPLSPTSSLGEERN
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| BDBM50433690 |
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| n/a |
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| Name | BDBM50433690 |
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| Synonyms: | CHEMBL2381150 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H18F2N2O5 |
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| Mol. Mass. | 440.3962 |
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| SMILES | COc1cc(F)c(F)cc1-c1ccc(OCc2cccc3c2[nH]n(CC(O)=O)c3=O)cc1 |
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| Structure | 
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