| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM50435216 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_963503 (CHEMBL2394384) |
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| EC50 | 20000±n/a nM |
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| Citation |  Zhang, P; Yang, X; Zhang, F; Gabelli, SB; Wang, R; Zhang, Y; Bhat, S; Chen, X; Furlani, M; Amzel, LM; Liu, JO; Ma, D Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg Med Chem21:2600-17 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43220.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
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| Residue: | 386 |
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| Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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| BDBM50435216 |
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| n/a |
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| Name | BDBM50435216 |
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| Synonyms: | CHEMBL2392901 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H34ClN7O2 |
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| Mol. Mass. | 524.058 |
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| SMILES | COc1cccc(n1)-c1nc(C)c(Cl)c(NC[C@H](NC(=O)CCCN2CCNCC2)c2ccccc2)n1 |r| |
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| Structure | 
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