Reaction Details |
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Target | Cytochrome P450 2C9 |
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Ligand | BDBM50435758 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_965762 (CHEMBL2393701) |
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IC50 | 63±n/a nM |
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Citation | Thalji, RK; McAtee, JJ; Belyanskaya, S; Brandt, M; Brown, GD; Costell, MH; Ding, Y; Dodson, JW; Eisennagel, SH; Fries, RE; Gross, JW; Harpel, MR; Holt, DA; Israel, DI; Jolivette, LJ; Krosky, D; Li, H; Lu, Q; Mandichak, T; Roethke, T; Schnackenberg, CG; Schwartz, B; Shewchuk, LM; Xie, W; Behm, DJ; Douglas, SA; Shaw, AL; Marino, JP Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett23:3584-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 2C9 |
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Name: | Cytochrome P450 2C9 |
Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 55636.33 |
Organism: | Homo sapiens (Human) |
Description: | P11712 |
Residue: | 490 |
Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
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BDBM50435758 |
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n/a |
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Name | BDBM50435758 |
Synonyms: | CHEMBL2392693 |
Type | Small organic molecule |
Emp. Form. | C24H31F3N6O |
Mol. Mass. | 476.5377 |
SMILES | CNc1nc(nc(n1)N1CCC(CC1)C(=O)NCc1ccccc1C(F)(F)F)C1CCCCC1 |
Structure |
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