Reaction Details |
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Target | Bifunctional epoxide hydrolase 2 |
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Ligand | BDBM50435745 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_965766 (CHEMBL2393705) |
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IC50 | 3.0±n/a nM |
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Citation | Thalji, RK; McAtee, JJ; Belyanskaya, S; Brandt, M; Brown, GD; Costell, MH; Ding, Y; Dodson, JW; Eisennagel, SH; Fries, RE; Gross, JW; Harpel, MR; Holt, DA; Israel, DI; Jolivette, LJ; Krosky, D; Li, H; Lu, Q; Mandichak, T; Roethke, T; Schnackenberg, CG; Schwartz, B; Shewchuk, LM; Xie, W; Behm, DJ; Douglas, SA; Shaw, AL; Marino, JP Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett23:3584-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bifunctional epoxide hydrolase 2 |
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Name: | Bifunctional epoxide hydrolase 2 |
Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
Type: | Enzyme |
Mol. Mass.: | 62613.07 |
Organism: | Homo sapiens (Human) |
Description: | P34913 |
Residue: | 555 |
Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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BDBM50435745 |
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n/a |
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Name | BDBM50435745 |
Synonyms: | CHEMBL2392706 |
Type | Small organic molecule |
Emp. Form. | C19H23F3N6O2 |
Mol. Mass. | 424.4201 |
SMILES | CNc1nc(C)nc(n1)N1CCC(CC1)C(=O)NCc1ccccc1OC(F)(F)F |
Structure |
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