| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2C9 |
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| Ligand | BDBM50435784 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_966356 (CHEMBL2396489) |
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| IC50 | 750±n/a nM |
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| Citation |  Gunzner-Toste, J; Zhao, G; Bauer, P; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Fu, B; Han, B; Ho, YC; Kley, N; Liang, X; Liederer, BM; Lin, J; Mukadam, S; O'Brien, T; Oh, A; Reynolds, DJ; Sharma, G; Skelton, N; Smith, CC; Sodhi, J; Wang, W; Wang, Z; Xiao, Y; Yuen, PW; Zak, M; Zhang, L; Zheng, X; Bair, KW; Dragovich, PS Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorg Med Chem Lett23:3531-8 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2C9 |
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| Name: | Cytochrome P450 2C9 |
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| Synonyms: | (R)-limonene 6-monooxygenase | (S)-limonene 6-monooxygenase | CP2C9_HUMAN | CYP2C10 | CYP2C9 | CYPIIC9 | Cytochrome P450 2C9 (CYP2C9 ) | Cytochrome P450 2C9 (CYP2C9) | P-450MP | P450 MP-4/MP-8 | P450 PB-1 | S-mephenytoin 4-hydroxylase |
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| Type: | Enzyme |
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| Mol. Mass.: | 55636.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11712 |
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| Residue: | 490 |
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| Sequence: | MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
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| BDBM50435784 |
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| n/a |
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| Name | BDBM50435784 |
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| Synonyms: | CHEMBL2393190 | US11279687, Compound 134 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H24N4O4S |
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| Mol. Mass. | 404.483 |
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| SMILES | C[C@H]1CN(C[C@@H](C)O1)S(=O)(=O)c1ccc(NC(=O)NCc2cccnc2)cc1 |r| |
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| Structure | 
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