Reaction Details |
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Target | Nicotinamide phosphoribosyltransferase |
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Ligand | BDBM50435777 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_966359 (CHEMBL2396492) |
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IC50 | 6.0±n/a nM |
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Citation | Gunzner-Toste, J; Zhao, G; Bauer, P; Baumeister, T; Buckmelter, AJ; Caligiuri, M; Clodfelter, KH; Fu, B; Han, B; Ho, YC; Kley, N; Liang, X; Liederer, BM; Lin, J; Mukadam, S; O'Brien, T; Oh, A; Reynolds, DJ; Sharma, G; Skelton, N; Smith, CC; Sodhi, J; Wang, W; Wang, Z; Xiao, Y; Yuen, PW; Zak, M; Zhang, L; Zheng, X; Bair, KW; Dragovich, PS Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorg Med Chem Lett23:3531-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nicotinamide phosphoribosyltransferase |
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Name: | Nicotinamide phosphoribosyltransferase |
Synonyms: | NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1 |
Type: | Enzyme |
Mol. Mass.: | 55524.98 |
Organism: | Homo sapiens (Human) |
Description: | P43490 |
Residue: | 491 |
Sequence: | MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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BDBM50435777 |
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n/a |
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Name | BDBM50435777 |
Synonyms: | CHEMBL2393163 |
Type | Small organic molecule |
Emp. Form. | C21H27N5O3S |
Mol. Mass. | 429.536 |
SMILES | O=C(NCc1cccnc1)Nc1ccc(cc1)S(=O)(=O)N1CCC2(CCNC2)CC1 |
Structure |
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