| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM50437326 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_972464 (CHEMBL2412834) |
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| IC50 | >50000±n/a nM |
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| Citation |  Wangtrakuldee, P; Byrd, MS; Campos, CG; Henderson, MW; Zhang, Z; Clare, M; Masoudi, A; Myler, PJ; Horn, JR; Cotter, PA; Hagen, TJ Discovery of Inhibitors of ACS Med Chem Lett4:699-703 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 43220.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells. |
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| Residue: | 386 |
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| Sequence: | MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
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| BDBM50437326 |
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| n/a |
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| Name | BDBM50437326 |
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| Synonyms: | CHEMBL2407599 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H15ClN2O2 |
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| Mol. Mass. | 278.734 |
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| SMILES | Oc1c(CN2CCOCC2)cc(Cl)c2cccnc12 |
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| Structure | 
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