Reaction Details |
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Target | Sphingosine kinase 2 |
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Ligand | BDBM50438155 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_972985 (CHEMBL2412223) |
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IC50 | 430±n/a nM |
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Citation | Gustin, DJ; Li, Y; Brown, ML; Min, X; Schmitt, MJ; Wanska, M; Wang, X; Connors, R; Johnstone, S; Cardozo, M; Cheng, AC; Jeffries, S; Franks, B; Li, S; Shen, S; Wong, M; Wesche, H; Xu, G; Carlson, TJ; Plant, M; Morgenstern, K; Rex, K; Schmitt, J; Coxon, A; Walker, N; Kayser, F; Wang, Z Structure guided design of a series of sphingosine kinase (SphK) inhibitors. Bioorg Med Chem Lett23:4608-16 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sphingosine kinase 2 |
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Name: | Sphingosine kinase 2 |
Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
Type: | Protein |
Mol. Mass.: | 69221.44 |
Organism: | Homo sapiens (Human) |
Description: | Q9NRA0 |
Residue: | 654 |
Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
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BDBM50438155 |
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n/a |
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Name | BDBM50438155 |
Synonyms: | CHEMBL2409881 |
Type | Small organic molecule |
Emp. Form. | C23H26ClN3O2S |
Mol. Mass. | 443.989 |
SMILES | OC[C@H]1C[C@@H](O)CCN1CCc1ccc(Nc2nc(cs2)-c2ccccc2Cl)cc1 |r| |
Structure |
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