Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50438724 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_976373 (CHEMBL2415509) | ||
IC50 | 131±n/a nM | ||
Citation | Dow, RL; Andrews, MP; Li, JC; Michael Gibbs, E; Guzman-Perez, A; Laperle, JL; Li, Q; Mather, D; Munchhof, MJ; Niosi, M; Patel, L; Perreault, C; Tapley, S; Zavadoski, WJ Defining the key pharmacophore elements of PF-04620110: discovery of a potent, orally-active, neutral DGAT-1 inhibitor. Bioorg Med Chem21:5081-97 (2013) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Protein | ||
Mol. Mass.: | 55297.82 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O75907 | ||
Residue: | 488 | ||
Sequence: |
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BDBM50438724 | |||
n/a | |||
Name | BDBM50438724 | ||
Synonyms: | CHEMBL2414696 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H26N4O4 | ||
Mol. Mass. | 410.4662 | ||
SMILES | Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CCC(O)=O)CC3)C(=O)c12 |r,wU:16.16,wD:19.20,(10.74,-43.8,;10.71,-45.35,;9.35,-46.09,;9.32,-47.63,;10.64,-48.44,;12,-47.69,;13.18,-48.7,;14.7,-48.38,;15.4,-47,;14.74,-45.58,;15.76,-44.38,;17.26,-44.66,;18.25,-43.5,;17.73,-42.02,;16.23,-41.78,;15.24,-42.95,;18.74,-40.83,;18.22,-39.39,;19.21,-38.22,;20.71,-38.46,;21.72,-37.27,;23.23,-37.55,;24.23,-36.37,;25.75,-36.65,;23.71,-34.91,;21.23,-39.93,;20.24,-41.1,;13.26,-45.22,;12.96,-43.7,;12.03,-46.15,)| | ||
Structure |