Reaction Details |
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Target | DNA topoisomerase 4 subunit A/B |
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Ligand | BDBM50440318 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_982977 (CHEMBL2427061) |
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IC50 | 2000±n/a nM |
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Citation | Surivet, JP; Zumbrunn, C; Rueedi, G; Hubschwerlen, C; Bur, D; Bruyère, T; Locher, H; Ritz, D; Keck, W; Seiler, P; Kohl, C; Gauvin, JC; Mirre, A; Kaegi, V; Dos Santos, M; Gaertner, M; Delers, J; Enderlin-Paput, M; Boehme, M Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity. J Med Chem56:7396-415 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA topoisomerase 4 subunit A/B |
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Name: | DNA topoisomerase 4 subunit A/B |
Synonyms: | Topoisomerase IV |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 2012758 |
Components: | This complex has 2 components. |
Component 1 |
Name: | DNA topoisomerase 4 subunit A |
Synonyms: | PARC_STAAU | Topoisomerase IV subunit A | grlA | parC |
Type: | PROTEIN |
Mol. Mass.: | 91040.14 |
Organism: | Staphylococcus aureus |
Description: | ChEMBL_340188 |
Residue: | 800 |
Sequence: | MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNF
RKSAKTVGDVIGQYHPHGDFSVYKAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYT
EAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIP
PHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR
SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIA
IELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVAN
RTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEVFEFTEEQAEAI
VMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL
SLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKH
QEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFN
TDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNK
GMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKI
LQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYT
NGSFIVDTDDFGEVIDMYIS
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Component 2 |
Name: | DNA topoisomerase 4 subunit B |
Synonyms: | DNA topoisomerase 4 subunit B | DNA topoisomerase 4 subunit B (parE) | PARE_STAA8 | Topoisomerase IV subunit B | grlB | parE |
Type: | Enzyme |
Mol. Mass.: | 74365.92 |
Organism: | Staphylococcus aureus |
Description: | Q2FYS5 |
Residue: | 663 |
Sequence: | MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEI
DVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGA
SVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKAS
TSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLH
DVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYAR
RINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADK
LPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKN
TEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTI
GAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLY
KLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTL
IRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDE
EEI
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BDBM50440318 |
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n/a |
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Name | BDBM50440318 |
Synonyms: | CHEMBL2424897 |
Type | Small organic molecule |
Emp. Form. | C23H24N6O4S |
Mol. Mass. | 480.539 |
SMILES | COc1ccc2nccc(NC(=O)[C@@H]3CC[C@H](CO3)NCc3ccc4SCC(=O)Nc4n3)c2n1 |r| |
Structure |
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