Reaction Details |
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Target | Coagulation factor VII/Tissue factor |
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Ligand | BDBM50440826 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_984127 (CHEMBL2434648) |
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Ki | 197±n/a nM |
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Citation | Glunz, PW; Zhang, X; Zou, Y; Delucca, I; Nirschl, AH; Cheng, X; Weigelt, CA; Cheney, DL; Wei, A; Anumula, R; Luettgen, JM; Rendina, AR; Harpel, M; Luo, G; Knabb, R; Wong, PC; Wexler, RR; Priestley, ES Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors. Bioorg Med Chem Lett23:5244-8 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Coagulation factor VII/Tissue factor |
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Name: | Coagulation factor VII/Tissue factor |
Synonyms: | Coagulation factor III/Factor VIIa (fVIIa) | Coagulation factor III/VII |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 69535 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Tissue factor |
Synonyms: | CD_antigen=CD142 | Coagulation factor III | Coagulation factor VII/tissue factor | F3 | TF | TF_HUMAN | Thromboplastin | Tissue factor |
Type: | PROTEIN |
Mol. Mass.: | 33067.61 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_936735 |
Residue: | 295 |
Sequence: | METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPK
PVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGS
AGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFG
KDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVE
CMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
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Component 2 |
Name: | Coagulation factor VII |
Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
Type: | Enzyme |
Mol. Mass.: | 51599.89 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 466 |
Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
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BDBM50440826 |
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n/a |
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Name | BDBM50440826 |
Synonyms: | CHEMBL2431605 |
Type | Small organic molecule |
Emp. Form. | C29H32N4O5S |
Mol. Mass. | 548.653 |
SMILES | CCOc1cc(ccc1OC(C)C)C(Nc1ccc2c(N)nccc2c1)C(=O)NS(=O)(=O)c1ccc(C)cc1 |
Structure |
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